It would take a confluence of events for that to happen - first, he would need to be perceived by his base as not fulfilling some of his primary campaign promises. Most notably building the wall, repeal and replace Obamacare, drain the swamp etc. He's well on his way of not doing any of those. Second, he would need to be dogged by persistent conflict of interest rumors related to his business, Russia, et al. Third, he would need to be perceived as incompetent and a puppet of foreign influence who continues to use his Presidency to shield himself from further investigation into the matter. Fourth, he would need to be plagued by something he does that is considered impeachable (such as being in violation of the emoluments clause on day 1). And fifth and most importantly, he would have to do something to estrange himself from Ryan and McConnell so that they view him as more of an impediment than a vehicle towards enacting their agenda. If all five of these things happen, he will be on very thin ice.