SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

It's quite incredible and also scary that in the space of about 3 weeks Boris has gone from bragging about shaking hands with patients to being in intensive care. I hope he pulls through this. There's also a clap for him tomorrow night apparently.

Got no interest or joy in the geezer dying but a fecking clap? Get stuffed.
 
It's quite incredible and also scary that in the space of about 3 weeks Boris has gone from bragging about shaking hands with patients to being in intensive care. I hope he pulls through this. There's also a clap for him tomorrow night apparently.

It's really crazy.
 
Are you alluding that the people working around the clock to try to save lives in the ICUs around the world aren't doing their best for the patients that aren't the prime minister, and that they could squeeze out an extra 5% of good old fashioned healthcare if the patient's important enough?

If so, you might want to rethink that incredibly disrespectful armchair statement. Have you ever been to an ICU and seen what goes on?

It wasn't aimed in the slightest against doctors. I meant it purely in a macro sense. Where I assume ICU personnel usually have to divide their attention and resources between several patients (or worse, if they got hit hard by the virus), I assume that BoJo as PM will either already have a dedicated doctor or someone in a suit will pull a doctor and tell them they have basically one patient now.
 
Which are these 'two companies' who have some kind of magic dust?
Guardian: Some context on Trump’s claim he is working with the FDA and companies are ready to assist London:

In the week beginning 30 March, the Food and Drug Administration (FDA) provided hydroxychloroquine with an “emergency use authorisation” to use on coronavirus patients in some circumstances. State officials in New York have said that about 4,000 seriously ill patients are now being treated with the drug.

But critics point out a side effect is heart stoppage, meaning the drug is potentially deadly. Some medical experts have called for the drug to be used to treat the virus but others have cautioned its need for more trials and controlled testing to avoid worsening the pandemic.
 
I wonder what Boris's doctors think of Trump contacting them and interrupting them while they're working :rolleyes:

I bet he's pushing HCL too, the cnut.

Don't be surprised if Bojo's partner opts for the experimental Remsdivir injection from Gilead (screw HCL). As he's a PM, he'll have privileged access to it, rightfully so. Good advert for Gilead too if it works. Hush, Hush if it doesn't.
 
It wasn't aimed in the slightest against doctors. I meant it purely in a macro sense. Where I assume ICU personnel usually have to divide their attention and resources between several patients (or worse, if they got hit hard by the virus), I assume that BoJo as PM will either already have a dedicated doctor or someone in a suit will pull a doctor and tell them they have basically one patient now.


I think that's fair although I get why he got a bit shirty with you.
 
But critics point out a side effect is heart stoppage, meaning the drug is potentially deadly.
Thats ok. Most drugs in US are advertised on TV with disclaimers like "Known side effects include headache, nausea, diarrhea, breathing problems, heart stoppage, brain hemorrhage and death" or 'This medicines were effective in almost 95% of patients. Rest died"
 
Or maybe he’s just a concerned friend?
Even if he is, do you think all concerned friends should call into the ICU to check up on him? I mean, he's probably got lots of concerned friends. Do you think that nurses and doctors should spend their time on the phone or by the patient's side?
 
Guardian: Some context on Trump’s claim he is working with the FDA and companies are ready to assist London:

In the week beginning 30 March, the Food and Drug Administration (FDA) provided hydroxychloroquine with an “emergency use authorisation” to use on coronavirus patients in some circumstances. State officials in New York have said that about 4,000 seriously ill patients are now being treated with the drug.

But critics point out a side effect is heart stoppage, meaning the drug is potentially deadly. Some medical experts have called for the drug to be used to treat the virus but others have cautioned its need for more trials and controlled testing to avoid worsening the pandemic.
Is this the same drug used for Malaria?
 
Just FYI. Bottom line is nobody know if hydroxychloroquine works. But as far as I know every inpatient in USA gets it. I have seen improvement in some patients but does nothing in ICU patients. Makes you think the improvement was just luck. But no one knows. In the meanwhile we use it cuz we want to feel like we are treating it. And the patients and families want to feel the same.
 


Wishes Boris, his family and the British people all the best, and a quick recovery to Boris in particular.

Didn't know he had a baby on the way. Hopefully he makes a full recovery and we get some good news in the coming days.
 
Even if he is, do you think all concerned friends should call into the ICU to check up on him? I mean, he's probably got lots of concerned friends. Do you think that nurses and doctors should spend their time on the phone or by the patient's side?
If the president of the USA phones then yeah. You answer the fecking phone.
 
Don't be surprised if Bojo's partner opts for the experimental Remsdivir injection from Gilead (screw HCL). As he's a PM, he'll have privileged access to it, rightfully so. Good advert for Gilead too if it works. Hush, Hush if it doesn't.

You are right. He will probably get remdesivir. Another one we don't know if works or not. He probably will also get convalescent covid plasma.
 
Or maybe he’s just a concerned friend?
Likely to have called someone at the US embassy or someone from BJ's PR team. Trump is a stranger to the truth. Very unlikely he'd have a doctors number.
 
Got no interest or joy in the geezer dying but a fecking clap? Get stuffed.

Indeed. Not going to wish death on him, but fecked if I’m clapping for a racist, homophobic leader of a party who laugh at the idea of poor people having to beg for food from food banks. I’ll save that for the sick and dead frontline workers who might not be either of those things if the NHS had enough supplies.
 
Both drugs being used to treat COVID. Won’t know which one works better (or works at all) until we get some RCT results.

Here in USA no one is using chloroquine as far as I am aware. Probably because chloroquine is not easily available here.

On a related note:

 
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It wasn't aimed in the slightest against doctors. I meant it purely in a macro sense. Where I assume ICU personnel usually have to divide their attention and resources between several patients (or worse, if they got hit hard by the virus), I assume that BoJo as PM will either already have a dedicated doctor or someone in a suit will pull a doctor and tell them they have basically one patient now.
Obviously, you could be right, but I honestly have a hard time seeing, considering the scheduling nightmares that the opening of x number of new ICUs has caused, that they can just pull another three teams (to cover 24 hours a day 7 days per week) of doctors and nurses out of that schedule to care for one patient. That assumes that those people have been sitting on their arses up until now, which I can't really see. If they're pulling them out of the regular schedule to care for him and him alone, then they are going to stretch the others much further and potentially harm other patients.

And despite my perspective being that of a doctor's, don't forget the nurses in all of this. They're at the patient's side more than we are (and have fewer patients assigned to them as a result), and they do a massive job with these patients.

Also, taking care of a patient with a respiratory problem doesn't require you to do things every minute. You often end up altering the settings on the ventilator, and then you wait 45 minutes and take a blood sample to evaluate the effect of that change (if not immediately apparent), so it really doesn't require 24/7 attention from a doctor's POV. Most of the time you can only react to deteriorations in the condition, so you might end up doing nothing for x hours if the patient's condition is stable.
 
Both drugs being used to treat COVID. Won’t know which one works better (or works at all) until we get some RCT results.
If these drugs are already in use then the likelihood of side-effects is surely known and likely not to be critical?
 
If these drugs are already in use then the likelihood of side-effects is surely known and likely not to be critical?

Cuz unless you do a randomized trial you don't know what's happening because of drug vs because of disease. Comparing 2 groups is the key.
 
I've had that feeling since last night. VDO below (shared a few days ago by @Raoul) easily explains how the virus evolves and wreaks his havoc, once it enters your body. Generally speaking, its not a major threat for vast vast majority of people. But when it becomes a problem, you are in serious trouble. The numbers also back that up.

My sister told me a few days ago the degradation post ICU can be very rapid and that she's overseen patients die within a few hours after entering ICU. There is very little doctors can do, aside from make you more comfortable, buy your immune system some extra time via a ventilator, and hope your body can repair itself.

The language in the Press Release is written by savvy spin doctors, trying their best to make it sound least alarming as possible. But Im in no doubt, BoJo has entered the genuine problem phase, and could be just hours away from his end.



Excellent video, everyone should watch it.
 
Cuz unless you do a randomized trial you don't know what's happening because of drug vs because of disease. Comparing 2 groups is the key.

You won’t know about disease specific side effects without a comparator but he’s right that we know a hell of a lot about their overall safety profile, which makes them a relatively safe option compared to the alternatives.
 
If the president of the USA phones then yeah. You answer the fecking phone.
Bollocks. Are you seriously suggesting that healthcare professionals should stop what they're doing to inform a non-relative of his condition, just because he's a little curious and he happens to call himself a friend of his? Do we know if he'd have wanted that? Where do you draw the line? Should they stop to answer questions if Macron calls? Merkel? Löfven? Putin? Xi? His neighbour? The cleaning lady?

There are channels for that info and IMO none of them should be Trump calling straight into the ICU. Give the poor man some fecking privacy in his critical illness for feck's sake.

Now, I really think Trump's full of shit and he hasn't done any of that, but anyway.
 
You won’t know about disease specific side effects without a comparator but he’s right that we know a hell of a lot about their overall safety profile, which makes them a relatively safe option compared to the alternatives.

What I mean is chloroquine was active in vitro against ebola virus. However in the trial patients who got chloroquine did worse. Not sure what outcomes they measured. But my point is you are right we know more about chloroquine and hcq and nowhere near enough about remdesivir but when it comes to specific diseases you just don't know how things workout without RCTs.

Are you icu or ED or general medicine?
 
Can they administer all of them and hope for the best?

You don't want to do that. Too much potential for side effects particularly when you don't even know the efficacy of treatment to begin with.
 
If the president of the USA phones then yeah. You answer the fecking phone.

The President of the USA is not allowed to call anyone and especially any foreign leader without the proper protocol. Neither is a foreign leader allowed to answer it without the correct protocol.
 
You don't want to do that. Too much potential for side effects particularly when you don't even know the efficacy of treatment to begin with.
Even if PM's life is hanging by a thread? Last chance saloon?