I think I've been resigned to the idea we'll be living with this from now on for a while. It's about finding ways to live with it that allows people to live normal lives and minimises the amount of people it kills.
50% effectiveness sounds rubbish but actually that's a potential game changer. If you can give a majority of vulnerable people a vaccine that gives them a 50% chance of being immune to the virus then you can imagine the difference that makes. If you can find a way to give that vaccine to a majority of people in general, then even the vulnerable people who the vaccine doesn't work for will be far less likely to catch it off someone else in the first place.
If you couple that with treatments and preperation getting better, and the hope (admittedly that's what it is at the moment) the virus will become less dangerous, then you are into the realms of being able to let people function and live out their lives without covid being a factor at every single corner.
I think my bigger scepticism with vaccines is how effectively they'll be distributed and how willing people will be to have them. Longer term carrying on as things have been this year will go out of the window one way or another, so it's all about bringing down the risk factor to normal day to day life I think. The idea of getting rid of the virus as a threat completely doesn't really add up to me. If people can catch it, recover and then catch it again it's unlikely to go away.