SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

"UCSF and UCBerkeley have donated their research labs to process kits. But each has capacity to process only 20-40 kits per day. And are not clinically certified. "

Not very comforting
 
Every few years there seems another: SARS, Ebola, MERS, H1N1, COVID-19. Growing strains of antibiotic resistant bacteria. Are we in the twilight of a century of medicine’s great triumph over infectious disease?
 
Professor John Ashton just on James O'Brien seemingly suggesting that the governments strategy amounts to a bit of a hail Mary pass because they appear so far behind where they should be in preparedness.
 
Every few years there seems another: SARS, Ebola, MERS, H1N1, COVID-19. Growing strains of antibiotic resistant bacteria. Are we in the twilight of a century of medicine’s great triumph over infectious disease?

Maybe in the short term, I think long term we'll be fine but the growth and global interconnectivity of China has increased the risks for the wider world.
 
Well he's already conceeded people will die, and he's letting people get infected in order to develop immunity. I think this plan is flawed because we don't even know if letting people get it will actually make them immune.

That's an extremely scary factor, Is there factual evidence that immunity is guranteed because if that is not the case 10000s in the UK will die for little to no reason apart from keeping the economy running for a few more days.
Of little surprise with this government though.
 
The Lancet is one of the most respected, long running Medical journals out there, right?

Really surprised more people aren't talking about these comments from them! Very telling comments from their Editor.

Ive very limited knowledge but from everything I've heard thus far, Lancet seems very respected. Make of that what you will.
 
All elite football in England has been suspended until at least 3 April as a result of the spread of coronavirus.

All Premier League games, EFL fixtures and matches in the FA Women's Super League and Women's Championship have been postponed.
 
Every few years there seems another: SARS, Ebola, MERS, H1N1, COVID-19. Growing strains of antibiotic resistant bacteria. Are we in the twilight of a century of medicine’s great triumph over infectious disease?

Viruses can't be treated with antibiotics.
 
Every few years there seems another: SARS, Ebola, MERS, H1N1, COVID-19. Growing strains of antibiotic resistant bacteria. Are we in the twilight of a century of medicine’s great triumph over infectious disease?
Pretty sure this is viral not bacterial, so anti-bitotics wouldn't have helped.
 
The Lancet is one of the most respected, long running Medical journals out there, right?

Really surprised more people aren't talking about these comments from them! Very telling comments from their Editor.

Yes, one of them. Keep in mind, it doesn't necessarily mean it's gospel - they all make the occasional snafu.
 


This got a bit lost in the talk of the UK's general strategy but any idea where they got their 7 days recommendation from? Most other places seem to be saying 14.
 
South Korea have reported more recoveries than active cases. Yet, our government would have you believe that this cannot be controlled.
 
  • 40-70% of the US population will be infected over the next 12-18 months. After that level you can start to get herd immunity. Unlike flu this is entirely novel to humans, so there is no latent immunity in the global population.
  • [We used their numbers to work out a guesstimate of deaths— indicating about 1.5 million Americans may die. The panelists did not disagree with our estimate. This compares to seasonal flu’s average of 50K Americans per year. Assume 50% of US population, that’s 160M people infected. With 1% mortality rate that's 1.6M Americans die over the next 12-18 months.]
What is 'herd immunity'?
 
My professors and my sleepy little town are becoming famous on the global scale through all this.

https://www.nytimes.com/2020/03/11/world/europe/italy-coronavirus.html?smid=fb-share

For Italians, Dodging Coronavirus Has Become a Game of Chance
Daily life in Italy is now a roll of the dice. Just ask residents of Pavia, once home to a founder of modern probability theory.

In Italy, at least, there is no better place to assess those odds than Pavia. The handsome town of about 75,000 sits south of Milan, in the middle of the hard hit Lombardy region, and is known as the Las Vegas of Italy for its abundance of slot and lotto machines.

More than that, Pavia is famed as the home of Gerolamo Cardano, a 16th-century mathematician and doctor. His father was an associate of Leonardo da Vinci, his siblings succumbed to the plague, and his terrible luck at gambling inspired him to try to divine whether the dictates of fate could be predicted and calculated.

In the intensive care unit of a Pavia hospital, doctors are treating a person known as Patient One, a previously healthy 38-year-old runner who is believed to have helped spread the virus around the Lombardy region.

The hospital’s doctors are busy calculating the probability of contagion, illness and death. Dr. Raffaele Bruno, director of the infectious disease unit at the San Matteo Hospital in Pavia, said they were compiling a data set to help international colleagues have a better sense of the stakes.

“You can calculate the odds when you have the numbers,” said Fausto Baldanti, a virologist at the San Matteo Hospital in Pavia. “If you don’t have the numbers, everything is hypothetical.”

He said that the hospital’s early efforts to separate coronavirus patients from others had helped bring the death rate down, as had what he called a “huge expansion of the intensive care units.”

Those rigorous measures in the Lombardy region reduced the number of serious cases and deaths, he noted. Nevertheless the virus’s toll in Italy has continued to rise, this week surpassing 12,000 infections and more than 800 deaths.

The overload of the system, he said, meant that care was not a constant.
On Wednesday, Giorgio Gori, the mayor of Bergamo, a town in Lombardy, who had written on Twitter that intensive care units had become so overloaded that “the patients who cannot be treated are left to die,” said in an interview that doctors were forced to write off those with “smaller chances of survival.”
 
  • 40-70% of the US population will be infected over the next 12-18 months. After that level you can start to get herd immunity. Unlike flu this is entirely novel to humans, so there is no latent immunity in the global population.
  • [We used their numbers to work out a guesstimate of deaths— indicating about 1.5 million Americans may die. The panelists did not disagree with our estimate. This compares to seasonal flu’s average of 50K Americans per year. Assume 50% of US population, that’s 160M people infected. With 1% mortality rate that's 1.6M Americans die over the next 12-18 months.]
What is 'herd immunity'?

If enough people are immune, the virus can't 'move'; even if you and another person aren't immune, the virus is blocked off by all the immune people ('the immune herd') in between you two. Kind of like crossing a stepping stone bridge and there aren't enough stones. It's not true complete immunity, just a statistical/probability-based quality.

You've probably heard of the measles outbreaks happening due to the anti-vaxx movement. Those are examples of loss of herd immunity at work.
 
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Not necessarily. The government states they want herd immunity to stop this recurring, and to be able to manage demand on the health service. I assume the spread is currently at the rate they judge optimal for those two goals - and other measures will be introduced when the infection rate hits a certain level.

It's also worth pointing out that closing schools will take a load of staff out of the NHS at a moment where they are trying to prepare for the inevitable rise in cases.

This is well worth a read by the way:


Yeah. This will likely be the most significant event globally since the popularisation of the Internet. It will dwarf 9/11 in the impact of its ramifications.
 
  • 40-70% of the US population will be infected over the next 12-18 months. After that level you can start to get herd immunity. Unlike flu this is entirely novel to humans, so there is no latent immunity in the global population.
  • [We used their numbers to work out a guesstimate of deaths— indicating about 1.5 million Americans may die. The panelists did not disagree with our estimate. This compares to seasonal flu’s average of 50K Americans per year. Assume 50% of US population, that’s 160M people infected. With 1% mortality rate that's 1.6M Americans die over the next 12-18 months.]
What is 'herd immunity'?

Herd immunity is when a virus cannot be spread as easily as most of the "herd" are immune to it and fight it off. It's a term used a lot explaining to anti-vaxxers why they are selfish. Some children are allergic to injections/vaccinations so rely on other to be vaccinated and fight the virus before it can reach them.
 
As hard as Italy has been hit, Spain looks to be in real trouble.

They've gone from 600 cases to 4000 in 5 days. It took Italy 8 days to do the same.
Here there is a total lack of coordination. The government hold a demonstration for the Feminism and the next day they impose measures, but part of the government becomes infected/quarantine, and each region controls its health, so not everyone has closed schools.
Now people from Madrid are heading to vacation spots in different parts of the country.
On top Andalusia still refuses to cancel Easter :wenger:
 
  • 40-70% of the US population will be infected over the next 12-18 months. After that level you can start to get herd immunity. Unlike flu this is entirely novel to humans, so there is no latent immunity in the global population.
  • [We used their numbers to work out a guesstimate of deaths— indicating about 1.5 million Americans may die. The panelists did not disagree with our estimate. This compares to seasonal flu’s average of 50K Americans per year. Assume 50% of US population, that’s 160M people infected. With 1% mortality rate that's 1.6M Americans die over the next 12-18 months.]
What is 'herd immunity'?

Say there are 100 people in a town. 99 of them are immune to a disease, while 1 isn't. Someone from a new town comes in with the disease, it's unlikely that the 1 person who's not immune will get exposed to it because the other 99 can't catch it.
 
South Korea have reported more recoveries than active cases. Yet, our government would have you believe that this cannot be controlled.

This is what I am not understanding. Merkel said 70-80% of Germans may get it - that is 58 Million People or thereabouts. Johnson says lots more People in the UK will get it and die.

But China with a Population of 1.4bn seems to have topped out at around 80,000 cases (0.005% of their Population), the WHO confirms they are in decline and praised the Actions that they took.

How is it then that the rest of us are so fecked? Leaves me to believe that the Governments are only concerned with protecting their economy and not their people.
 
South Korea have reported more recoveries than active cases. Yet, our government would have you believe that this cannot be controlled.

They're doing things up to and including subpoenaing(?) wireless providers' handshake records to identify individuals who passed through high-exposure areas and track/vet/isolate them.
 


This got a bit lost in the talk of the UK's general strategy but any idea where they got their 7 days recommendation from? Most other places seem to be saying 14.

Just playing the odds it seems. Most self-isolating now for 7 days won’t have the coronavirus, and most that did will no longer spread it after 7 days. Absolutely there will be many that do have it and go on to spread it after 7 days in self isolation.
 
Worth remembering that there are 10 planned hospital closures in the pipeline for the next 6 months or so.

And no one from government has cancelled them.
 
Professor John Ashton just on James O'Brien seemingly suggesting that the governments strategy amounts to a bit of a hail Mary pass because they appear so far behind where they should be in preparedness.

Exactly. And what are they actually doing during this 'delay' phase? Are they sourcing and making space available for more beds? Are they reaching out for more medical help?
 


I've no problem with them writing that. It's an objective fact which a journalist has every right to discuss, as difficult or as controversial as that might be. In this case i don't think they were being malicious and you have to remember that the Telegraph's audience primarily consists of people in those brackets (elderly) so I don't think they are trying to incite the public to treat these people with contempt.

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Yeah. This will likely be the most significant event globally since the popularisation of the Internet. It will dwarf 9/11 in the impact of its ramifications.
What about the Sanchez/Mkhitaryan swap deal?
 
Why take any gamble then? The economy is going to be fecked anyway and the governments all have a great excuse for that now. So surely focusing purely on trying to save people's lives would be a good approach?

I suppose we are gambling either way. If the scientific advice is far fewer people are dead next year if we do it this way and its going to happen one way or the other then you have to go with that advice.

Fecked if I know what the right move is here.Herd thinking, going along with bad moves made by others to look like you are doing something are just as likely to end in more deaths.

Might be the UK govt is just being more honest about what we are facing, or they are useless shithouses. Well we know they are useless shithouses but you get my point.
 
Business as usual today in hospitals. Slightly unbelievable. We know this thing is in the community. They are risking passing this on to nurses, junior doctors, registrars and consultants. All of whom will be now expected to isolate for 7 days at the mere sign now of high fever or recurrent cough which honestly will mean last minutes sick calls that rota coordinators will not be able to get replacements/locums in for and massive harm to patients now let alone when this thing is at its peak.

If you don't want to do social isolation in certain respects then fine, but surely flattening the curve can be achieved in numerous more ways than has been currently proposed. Saddest part of this all is it won't be made political when its entirely political that chronic underinvestment in our critical care and other aspects of NHS will lead to deaths.
 
I've no problem with them writing that. It's an objective fact which a journalist has every right to discuss, as difficult or as controversial as that might be. In this case i don't think they were being malicious and you have to remember that the Telegraph's audience primarily consists of people in those brackets (elderly) so I don't think they are trying to incite the public to treat these people with contempt.

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My issue is less with them presenting that information and more the way it was expressed. For example, the use of the word "culling" in this context is less than appropriate.
 
Just playing the odds it seems. Most self-isolating now for 7 days won’t have the coronavirus, and most that did will no longer spread it after 7 days. Absolutely there will be many that do have it and go on to spread it after 7 days in self isolation.

The aim is not to eradicate transmission. That is not possible. The aim is to bring the reproductive number under 1. Presumably the government scientists think that can be done by bringing these measures in.

Only in Korea, China and Italy where the cases are already beyond the capacity of the health services do they need to act more aggressively, and the people are willing to accept it. In the early days of restrictions people in Italy mostly ignored them because they weren't scared of the virus. It doesn't sound like people in the UK are either.