SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

The opposite is actually the case. You can get a good idea about efficacy early (if it’s a very effective drug) but longer term data, with higher numbers of subjects exposed, is how you get a better understanding of the safety profile.

I'll see if I can find the article but it was a direct quote more or less from a virologist. He said that it is now very rare indeed for serious side effects not to show within 2 months but efficacy date often needed years to be really precise or accurate (I can't remember which) or maybe both.
 
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I'll see if I can find the article but it was a direct quote more or less from a virologist. He said that it is now very rare indeed for serious side effects not to show within 2 months but efficacy date often needed years to be really precise or accurate (I can't remember which) or maybe both.

Hmmm. Maybe it’s different for vaccines? Can’t think why though. The more people get exposed to a new drug the better your chance of uncovering rare, serious adverse events (which is particularly important for drugs given to very large numbers of not sick people)
 
Hmmm. Maybe it’s different for vaccines? Can’t think why though. The more people get exposed to a new drug the better your chance of uncovering rare, serious adverse events (which is particularly important for drugs given to very large numbers of not sick people)

I don't know and I was only going on the quote although it seemed a solid source at the time.

I'd guess it might be true but only as far as it goes. Rare is a relative term as well and as you say the longer the testing the greater the chance of identifying very rare side effects.

It was definitely in the context of the wisdom of the rapid approval of a covid vaccine and his point was that worrying about safety wasn't the big concern but effectiveness was less certain.

Of course the benefits of an effective vaccine with very rare but serious side effects is probably worth it to control or vastly reduce the impact of covid but that is a different if connected argument.

Dammit - I can't find it now. I'll keep looking.
 
On a side note. Can’t believe we still have fecking mink farms! Puts all the western sneering at China’s wet markets into perspective.
Incidentally I think the main market for mink fur is China.
Anyway, yeah I'm not a fan of mink farms.
 
Golf courses shut and Tennis (even outside) banned during lockdown.

Pathetic!
 


Good thread on “Danish mink mutation”

tl;dr Hopefully not a big deal but potentially worrying because of location of mutation (spike protein that Ab’s bind to) and the fact that Denmark have responded with such extreme measures.

Pretty irresponsible of Denmark not to immediately disseminate whatever information they are acting on.

Edit: never mind just read the second Twitter thread you posted.

Double edit: but they still don’t seem to have shared the actual data they have. That seems pretty important to disseminate, wonder why they haven’t.
 
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Pretty irresponsible of Denmark not to immediately disseminate whatever information they are acting on.

Edit: never mind just read the second Twitter thread you posted.

Double edit: but they still don’t seem to have shared the actual data they have. That seems pretty important to disseminate, wonder why they haven’t.

If you scroll down the second thread they do talk about notifying the WHO etc so maybe they intend sharing the data via that route? I’m actually a bit confused about the best way data likes these get shared nowadays. Would it be via a preprint on some sort of open source platform?
 
Furlough extended to march. They clearly dont think this is going away
actually think 2021 will be worse then 2020, can only see things getting worse, any vaccine is really just going to be a massive gamble as wont have been able to be tested properly.
 
Furlough extended to march. They clearly dont think this is going away

It isn't going away. Mass vaccination won't begin until March at best estimates.

Extending Furlough gives the economy a chance of bouncing back by protecting jobs. It's a good decision, albeit I expect the Government won't be funding 80% of wages by March.
 
It isn't going away. Mass vaccination won't begin until March at best estimates.

Extending Furlough gives the economy a chance of bouncing back by protecting jobs. It's a good decision, albeit I expect the Government won't be funding 80% of wages by March.
 
It isn't going away. Mass vaccination won't begin until March at best estimates.

Extending Furlough gives the economy a chance of bouncing back by protecting jobs. It's a good decision, albeit I expect the Government won't be funding 80% of wages by March.

Yeah it's being 'reviewed' in January with regards to employers contribution %.
 
I've stayed away from this page and COVID numbers as of late and just cracked on with work.
I had two patients, literally bed-neighbours, die within 2 minutes of each other today. Absolutely terrible. We were trying to help the first one, despite her being on maximal treatment (OptiFlow), and could see the gentleman next to her visibly entering the stages of dying in our eyes. Literally nothing we can do.

It's truly heartbreaking even after all these months. It's draining, and I'm absolutely shattered from those people who still don't take it seriously or those who say that "the government are releasing false numbers" or "ThEy pUt COVID oN the dEaTh cErtiFicAte even though they died of something else".

That is absolutely bollocks. In my 5 years of working as a doctor, I've completed more death certificates in the last 8 months than I have in the first 4 years of working combined - and not once have I put the words of COVID down unless that's the thing that's killed them.

I'm dreading the winter pressures already - our hospital is already beyond full capacity and the daily recording released the information that we have 102 COVID patients admitted at present. Granted, a certain percentage are asymptomatic who happen to have it along with another issue - but I'll tell you what - I'd love to see one of those patients round about now because I don't see them.

I completely understand that from a non-medical point of view, this is infuriating/terrible in a different manner to mine. Some people can't even work because of this. I couldn't imagine not working during the last few months. Staying at home with feck all to do for weeks intermittently sounds very shit.

Unfortunately, until a vaccine comes, people are going to have to accept this as a way of living for the time being.
Seeing a 50 and 60 odd year old dying today - with barely a medical co-morbidity to their name - is a daily reminder that it isn't a poxy virus.
I'm scared shitless for my parents. I don't want to see them just in case I manage to bring it to them on a strand of my hair.

Thanks for this. It's good to get a doctors perspective and direct experience.
 
Thanks for this. It's good to get a doctors perspective and direct experience.
Agreed, that’s a top post from clearly a caring person.

@Hernandez - BFA Can I ask you why you think that morons are saying ‘people are dying of something else but they’re putting Covid on the death certificate’?

My assumption was that Covid is what leads to other prevalent illnesses to become triggered and kill them, is that the case or am I way off?
 
Agreed, that’s a top post from clearly a caring person.

@Hernandez - BFA Can I ask you why you think that morons are saying ‘people are dying of something else but they’re putting Covid on the death certificate’?

My assumption was that Covid is what leads to other prevalent illnesses to become triggered and kill them, is that the case or am I way off?

I think some people(myself included) are confused about how many are dying "with corona" and how many are dying "because of corona". Which is why I appreciate hearing input directly from doctors working with this. In general i've been interested in the overall infection mortality rate. Btw I'm not trying to create a narrative to myself that it's "just the flu bro".
 
I think some people(myself included) are confused about how many are dying "with corona" and how many are dying "because of corona". Which is why I appreciate hearing input directly from doctors working with this. In general i've been interested in the overall infection mortality rate. Btw I'm not trying to create a narrative to myself that it's "just the flu bro".
Oh yeah 100% that’s kinda what I want to wrap my head around too, mainly because I’m sick of hearing these conspiracy theories and i can feel more confident in having that conversation.

I was under the assumption you don’t really die ‘of corona’ but corona opens the doors for more life threatening and prevalent illnesses to take over, but I’d be interested to hear a professional explain to me like the simpleton I am!
 
I think some people(myself included) are confused about how many are dying "with corona" and how many are dying "because of corona". Which is why I appreciate hearing input directly from doctors working with this. In general i've been interested in the overall infection mortality rate. Btw I'm not trying to create a narrative to myself that it's "just the flu bro".
Oh yeah 100% that’s kinda what I want to wrap my head around too, mainly because I’m sick of hearing these conspiracy theories and i can feel more confident in having that conversation.

I was under the assumption you don’t really die ‘of corona’ but corona opens the doors for more life threatening and prevalent illnesses to take over, but I’d be interested to hear a professional explain to me like the simpleton I am!

You can definitely “die of corona” and that’s what’s happening to the vast majority of deaths that show up on the daily stats.

It can get a bit muddy when very old or very unwell people catch the virus. For them the stress of the viral infection can take away their ability to compensate for a long term illness (e.g. chronic heart failure) so they die before their time from an illness that isn’t covid. It’s really just semantics though. They would still be alive if they didn’t catch the virus, even though it’s not the virus that would be considered as the cause of death.

Cause of death is an inexact science anyway. Most deaths don’t get a post mortem, so there’s always some guess work from the doctor’s filling out the form. And it’s definitely possible that some people coincidentally catch covid shortly before their time was up anyway. And the virus doesn’t accelerate that process at all. This will be a minority of cases and is massively exaggerated by idiots on social media with an anti-lockdown agenda.
 
Oh yeah 100% that’s kinda what I want to wrap my head around too, mainly because I’m sick of hearing these conspiracy theories and i can feel more confident in having that conversation.

I was under the assumption you don’t really die ‘of corona’ but corona opens the doors for more life threatening and prevalent illnesses to take over, but I’d be interested to hear a professional explain to me like the simpleton I am!

I'm not sure the distinction here makes much of a difference?

I don't have exact stats, but you can see with the huge excess mortality across the world in the first wave that it's killing far more than people who were frail or on their death bed already.

Even a lot of the 'underlying health conditions' include things like diabetes, hypertension etc that aren't going to kill anyone anytime soon and people who were living perfectly normal lives prior to covid.
 
Now we're all going to die because of some fecking mink(s)? Jesus.
 
Now we're all going to die because of some fecking mink(s)? Jesus.

It just a few miles northwest from where I live. If am I not posting in the next few days it's probably because I'm dead.
 
I agree - but mostly in the sense that he waited far too long, right? Once he got going, he got it fairly right (if I remember correctly), but at that point, the situation was already too far gone.

it was more than that -
Delayed the lockdown, delayed coordinating supplies, with doctors and nurses going without PPE, forced nuring homes to take patients from overcorwded hospitals, and shielded them from any liability for deaths that happen (and a ton happened as covid spread throughout the homes). Coincidentally he got a donation from nursing homes.

https://www.propublica.org/article/...y-for-covid-patients-prompts-more-controversy
https://www.theguardian.com/us-news/2020/may/26/andrew-cuomo-nursing-home-execs-immunity
https://www.propublica.org/article/...y-10-times-the-number-of-deaths-as-california

Since April he is one of the most popular politicians in the country. Btw, when googling for these links, which I remembered reading in May, few/none of the CNN or NYT articles that showed up carried anything about it. Propublica broke the delay story and David Sirota, a blogger, broke the liability story.
 
Can't wait for this in the UK! Shows what can be done, with the right approach, even without a vaccine

 
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Boris speaking at 5pm.

On the Radio they had a gym owner from Manchester on, saying she's stayed open and people coming in for classes. Hopefully she get's a full £10k fine, and then no further help for her business. Fine those attending £100, and then take their financial support away too imo.

Harder and tougher action is now needed against those who break these rules, because in 2-3 weeks we' re in a for a shit storm
 
it was more than that -
Delayed the lockdown, delayed coordinating supplies, with doctors and nurses going without PPE, forced nuring homes to take patients from overcorwded hospitals, and shielded them from any liability for deaths that happen (and a ton happened as covid spread throughout the homes). Coincidentally he got a donation from nursing homes.

https://www.propublica.org/article/...y-for-covid-patients-prompts-more-controversy
https://www.theguardian.com/us-news/2020/may/26/andrew-cuomo-nursing-home-execs-immunity
https://www.propublica.org/article/...y-10-times-the-number-of-deaths-as-california

Since April he is one of the most popular politicians in the country. Btw, when googling for these links, which I remembered reading in May, few/none of the CNN or NYT articles that showed up carried anything about it. Propublica broke the delay story and David Sirota, a blogger, broke the liability story.
I misremembered then!
 
I misremembered then!

Ya the only reason I knew these were because Sirota is an ex-Bernie staffer so his work spread a lot on left social media. It simply wasn't well-covered in the mainstream or right-wing media (for the right, it's because Mitch McConnell later copy-pasted the liability bill from Cuomo into a seante proposal).
 
I've stayed away from this page and COVID numbers as of late and just cracked on with work.
I had two patients, literally bed-neighbours, die within 2 minutes of each other today. Absolutely terrible. We were trying to help the first one, despite her being on maximal treatment (OptiFlow), and could see the gentleman next to her visibly entering the stages of dying in our eyes. Literally nothing we can do.

It's truly heartbreaking even after all these months. It's draining, and I'm absolutely shattered from those people who still don't take it seriously or those who say that "the government are releasing false numbers" or "ThEy pUt COVID oN the dEaTh cErtiFicAte even though they died of something else".

That is absolutely bollocks. In my 5 years of working as a doctor, I've completed more death certificates in the last 8 months than I have in the first 4 years of working combined - and not once have I put the words of COVID down unless that's the thing that's killed them.

I'm dreading the winter pressures already - our hospital is already beyond full capacity and the daily recording released the information that we have 102 COVID patients admitted at present. Granted, a certain percentage are asymptomatic who happen to have it along with another issue - but I'll tell you what - I'd love to see one of those patients round about now because I don't see them.

I completely understand that from a non-medical point of view, this is infuriating/terrible in a different manner to mine. Some people can't even work because of this. I couldn't imagine not working during the last few months. Staying at home with feck all to do for weeks intermittently sounds very shit.

Unfortunately, until a vaccine comes, people are going to have to accept this as a way of living for the time being.
Seeing a 50 and 60 odd year old dying today - with barely a medical co-morbidity to their name - is a daily reminder that it isn't a poxy virus.
I'm scared shitless for my parents. I don't want to see them just in case I manage to bring it to them on a strand of my hair.

Unfortunately though, it definitely is happening and I’d actually be surprised if you really haven’t seen it yourself.
 
Ya the only reason I knew these were because Sirota is an ex-Bernie staffer so his work spread a lot on left social media. It simply wasn't well-covered in the mainstream or right-wing media (for the right, it's because Mitch McConnell later copy-pasted the liability bill from Cuomo into a seante proposal).
Yeah, it might also be the case that I did not so much misremember, but just never got the complete picture of what happened in NY state. I read some criticism of Cuomo, but that was more about he slow he was to take this sufficiently seriously and get going; not on what still went wrong when he did take his measures. For that period, what I read was more about perceptions of his public persona.
 
Agreed, that’s a top post from clearly a caring person.

@Hernandez - BFA Can I ask you why you think that morons are saying ‘people are dying of something else but they’re putting Covid on the death certificate’?

My assumption was that Covid is what leads to other prevalent illnesses to become triggered and kill them, is that the case or am I way off?
I think some people(myself included) are confused about how many are dying "with corona" and how many are dying "because of corona". Which is why I appreciate hearing input directly from doctors working with this. In general i've been interested in the overall infection mortality rate. Btw I'm not trying to create a narrative to myself that it's "just the flu bro".

So the way death certificates work is that it's split into:
Part 1 - A), B) C) - A seems to be the main thing that kills someone, and then B) and C) are the medical issues that likely lead to 1A.
Part 2 - Other co-morbidities that the patient had but may not have directly contributed to that person's death.

Now when it comes to this topic, the thing I read the most is that "the government" or "the NHS" just puts Cornavirus-19 down on the death certificate even if they never died from it.

I think a good example is today where, once again, I had another woman pass away today. She became COVID positive on the very start of the month, and unfortunately picked up a bacterial pneumonia on top - given her weakened immune system. After 4 days, she passed away today. When it'll come to me doing her death certificate tomorrow, there's scope to say that 1A would be the Hospital-Acquired Pneumonia, and then 1B would be Coronavirus-19. I could quite easily put Coronavirus-19 down as Part A because quite frankly, she was doing so poorly with it in the first place that it's likely she was going to pass away from it sadly. The bacterial infection just seemed to catalyse everything.

Whether I put it as 1A or 1B is actually moot - at the end of the day, from what I see clinically, COVID-19 has killed this lady unfortunately.
Whether I put it as 1A or 1B, I don't think it should raise any controversy whether the government uses it as a figure towards the number of deaths - because it 100% played the major part in the death of this lady.

Now I keep hearing that people put COVID-19 down even if they were asymptomatic with it, or that they had it and had mild symptoms but was hit by a falling seagull from the air so "we have to put COVID down on the death certificate".
Of course the example I've used is preposterous but my point stands.

I've had patients that are asymptomatic from COVID, but have died from a brain bleed - but I have not put down COVID at all down on the death certificate because they aren't linked at all.
I have also never put COVID down on a death certificate "because they've had it at some stage in the last 28 days" and died. I've had a couple of patients die of a bog-standard bacterial pneumonia but had COVID (asymptomatic) almost a month prior - but I have not put COVID down on the death certificate because all the other tests pointed at it being a bacterial cause or an aspiration cause rather than viral COVID pneumonitis.

Long, lengthy post so I do apologise but I just thought I'd share what they bang on about when it comes to death certificates. I didn't want to bring more common presentations because naturally some have lost members of family through non-COVID conditions during the last few months and I think people do forget that. Medicine has continued despite COVID and we still deaths that are fully unrelated to COVID.

Unfortunately though, it definitely is happening and I’d actually be surprised if you really haven’t seen it yourself.

Fine, I can't speak for all doctors/hospitals. That is 100% true and maybe I shouldn't put a blanket statement like I said. But I've worked in two hospitals during the COVID pandemic, and from my experience in both, COVID has only ever been put on the death certificate only if it's played a massive contribution towards the death - and the vast, vast, vast majority - COVID is 1A. I am working on the Respiratory COVID ward, so granted we get the sickest COVIDs in the hospital before they are deemed to require intubation in ITU - so naturally I am going to see more deaths that are full barn-door COVID. But I also help the more junior members of the team on the non-COVID Respiratory ward - and work on calls where I see a whole concoction of presentations who may die on admission. In my current hospital, there's guidance for us to say to only put down COVID if its played a role in their deaths. I can safely say that I'm part of the cohort in my hospital who have seen more COVID in the last few months than anyone else in the hospital - which unfortunately means I've done a fair few death certificates so I feel I can hold a fairly valid opinion on this whole death certificates debacle.
 
Now we're all going to die because of some fecking mink(s)? Jesus.
It just a few miles northwest from where I live. If am I not posting in the next few days it's probably because I'm dead.

With the lockdown that just happened because of the cluster-5 mink corona, we'll probably never hear from Shamana again.