If everyone is fit and we can play a high line of Mazraoui, De Ligt, Martínez and Shaw, with Ugarte and Mainoo as double pivots, I’d like to see Mount left, Amad right, Bruno in the 10 and Zirkzee as the false 9. Pressing and high technical ability.
There will be mass rotation anyway with lots of games, but for me this gives us the best blend of players who can actually keep the ball, press intelligently, and link up together.
Rashford and Garnacho are still best off the bench with their pace, offering something different, or in a line up where we play on the counter. Hojlund provides a more orthodox option as a 9, Casemiro a rotation option in the pivot. Yoro, Dalot and Maguire have all the defensive positions covered etc.