I think our squad has a surprisingly good fit for Amorim, assuming he plays with a similar formation to how he plays at Sporting.
Onana is ideal.
The back 3 can be built pretty well out of the current CB options we have. I would guess it goes Martinez-Yoro-De Ligt, but I haven't seen enough of Yoro to know whether he'd be better in the middle or the right. The CBs left and right need to be decent passers, while the guy in the middle would be more like the person who steps up to do interceptions. Maguire and Evans would be fine backups for that system.
The midfield pairing calls for a ball winner and someone able to carry the ball forward, and good enough to get involved with intricate passing in support of the attackers. That is a perfect fit for Ugarte and Mainoo respectively. Casemiro and Eriksen would be a decent enough alternatives too.
Up front, in terms of style, there's a lot of ways to do two attackers behind a lone striker. The forward striker probably has to be Hojland, since they need to be someone who pushes defenders back and works the channels. That ain't Zirkzee. But behind him, there's a few combinations of Bruno, Amad, Zirkzee, Rashford and Garnacho that could potentially work. My preference would be Bruno/Amad, but we can experiement.
Wingback is probably the trickiest fit. Dalot and Maz are decent attacking fullbacks, but they're not true wingers. Rashford and Garnacho don't feel right. I suspect we'll see Dalot or Maz used on the right this season. A lot of people have suggested Antony as left wing back, and I'm sure we'll at least try that out, but god knows if it'll work. But these are bound to be priorities for us in the Jan or Summer transfer windows.
Other than wingback I think that the main worry I have about the formation is fitting in Rashford and Garnacho. Neither striker me as right for the lone striker role, and intricate play on the edge of the box isn't really their strengths. We can try them out there but it may not suit. They aren't wingbacks either. Rashford is probably in last chance saloon this season anyway, but it should be obvious that we have to find a role that suits Garnacho's strengths.
But aside from those worries, I don't see too many square pegs in round holes with formation. The bigger issue will just be getting good performances out of them.