It's one batch of AZ rather than the entire vaccine, no?
The vaccines | vaxxed boosted unvaxxed? New poll
- Thread starter Badunk
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It's one batch of AZ rather than the entire vaccine, no?
I don't think it'll make much difference to you, UK AZ supply is essentially all coming from UK production sites, while the EU supply is coming from EU sites. That's one of the things the EU got riled up about, when the EU sites hit problems with meeting their production targets.
I'm on the same page with being keen to get a vaccine asap. My wife got a call for her first dose for next week, so it's beginning to feel like there's an end in sight. Next week is also supposed to be when the UK are expecting to ramp up numbers again, so hopefully they can deliever ahead of time on getting everyone jabbed that wants it.
There are at least two problematic batches at the moment. Denmark, Norway and Iceland have stopped using the AstraZeneca vaccine in it's entirety, some other countries like Italy are just withdrawing the ones that have been associated with adverse events.
Thankfully the J&J vaccine was approved today and should start shipping in volume very quickly. Italy is supposed to get 7.3 million doses in Q2, which works out to about 55 million Europe wide.
Well I had my first AZ jab last Saturday. No adverse effects.... Yet!
Novavax have released their UK P3 and South Africa P2b data - more or less the same efficacy results as they put in their interim results at the end of January but with better confidence levels (more cases).
Efficacy was 96.4% (95% CI: 73.8, 99.5) against the original virus strain and 86.3% (95% CI: 71.3, 93.5) against the B.1.1.7/501Y.V1 variant circulating in the U.K (post hoc). The primary efficacy endpoint demonstrated an overall vaccine efficacy of 89.7% (95% CI: 80.2, 94.6). 106 cases were observed, with 10 in the vaccine group and 96 in the placebo group. NVX-CoV2373 was effective against severe disease: five severe[1] cases were observed in the study, and all occurred in the placebo group. Four of the five severe cases were attributed to the B.1.1.7/501Y.V1 variant. Fourteen days after dose 1, vaccine efficacy was 83.4% (95% CI: 73.6, 89.5).
https://ir.novavax.com/news-release...rms-high-levels-efficacy-against-original-and
Efficacy was 96.4% (95% CI: 73.8, 99.5) against the original virus strain and 86.3% (95% CI: 71.3, 93.5) against the B.1.1.7/501Y.V1 variant circulating in the U.K (post hoc). The primary efficacy endpoint demonstrated an overall vaccine efficacy of 89.7% (95% CI: 80.2, 94.6). 106 cases were observed, with 10 in the vaccine group and 96 in the placebo group. NVX-CoV2373 was effective against severe disease: five severe[1] cases were observed in the study, and all occurred in the placebo group. Four of the five severe cases were attributed to the B.1.1.7/501Y.V1 variant. Fourteen days after dose 1, vaccine efficacy was 83.4% (95% CI: 73.6, 89.5).
https://ir.novavax.com/news-release...rms-high-levels-efficacy-against-original-and
Good to hear. I felt like utter shit after mine, but only for about 12 hours.
Had my first does of AZ on Tuesday.
Woke up on Wednesday and felt like I'd been playing 5-a-side all afternoon. Really tired, muscles aching etc etc. However, today I feel absolutely fine and have no side effects at all apart from a tender upper arm.
Anybody else had this?
Woke up on Wednesday and felt like I'd been playing 5-a-side all afternoon. Really tired, muscles aching etc etc. However, today I feel absolutely fine and have no side effects at all apart from a tender upper arm.
Anybody else had this?
Yep, fairly common reaction to the first dose of the AZ/Oxford vaccine.
It floored me when I had mine - had to dose up on paracetamol. But passed after 36 hours or so. Roll on the second dose!
Is it any better than the others? I thought I read it only offered 66% protection?
Are they multiplying or are you losing control?
You can’t compare head to head. The more recent vaccines have been tested against trickier variants than the early ones. So can’t match their headline efficacy %s. Main thing is it works.
I was hoping you were gonna tell me it’s wrong and it’s actually higher
You’d better shape uphad to read that twice to get the joke
Israel's data on the Pfizer vaccine is amazingly positive.
0 deaths, only 4 severe cases among 523,000 Israelis fully vaccinated with Pfizer
- Real-world data from Israel suggests the Pfizer COVID-19 vaccine is 94% effective in preventing asymptomatic infections, meaning it could significantly reduce transmission.
- Israeli data shows the vaccine was also 97% effective in preventing symptomatic disease, severe disease and death.
- The analysis also shows real-world evidence of the vaccine’s effectiveness against a highly infectious variant of COVID-19 first discovered in Britain, known as B.1.1.7. More than 80% of the tested specimens when the analysis was conducted were variant B.1.1.7.
0 deaths, only 4 severe cases among 523,000 Israelis fully vaccinated with Pfizer
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It could be. We don’t know. We’re comparing apples with oranges.
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It's a single dose and easy to store, so it'll be good for vaccinating big numbers quickly.
Fantastic news. From what I’ve seen in various interviews, Pfizer seems to be holding up pretty good against the variants as well.
This seems pretty common irrespective of which brand one gets. I had a nearly identical experience with my Pfizer last week.
I was out for 36 hours after my first dose. Apparently the side effects are meant to be worse after the second dose. Due for mine in April. I think I might just preemptively tell the hospital I won't be in for two days
I'd be lying if I said I'm not a bit nervous about how bad I'll feel, even if it's only temporarily. Haven't felt that sick in years.Really makes you think about just how awful getting actual Covid might feel.
Got my first AZ shot today (Australia) sore arm and a headache. Took paracetamol and 7 hours later still only a dull ache in arm. Back for second dose first week of JUN.
As some epidemiologist said last week "the best vaccine is the one in your arm:
More seriously that is fantastic news. I can't wait.
Just had my first AZ dose this morning. Just a bit of a headache and an aching arm. My GP confirmed to me that I fell into group 6 of the priority levels which surprised me (mid-30's, healthy BMI, long term health condition but very stable, no respiratory issues).
The humorous part of the process was an eejit outside in his sunflower lanyard, saying that the pandemic was all government control. I had to point out the irony that he's stood in a queue waiting for a vaccine, but I think it was lost on him.
The humorous part of the process was an eejit outside in his sunflower lanyard, saying that the pandemic was all government control. I had to point out the irony that he's stood in a queue waiting for a vaccine, but I think it was lost on him.
Your the one
even got a juice box
Pretty well done. Picked a day and time, went and got it today was told twice that i was consenting to AZ and asked twice if i had concerns about potential issues. Afterwards you got a link to book again and a set date, the website blocked out dates so can't go before a set date block (around 10 weeks). Going this early i hoped for Pfizer, but honestly, any jab that can turn the disease into "the common cold" as Fauci talks about it, is good enough for me.
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Well feck... My mom took the Astra vaccine literally just a few minutes before these news rolled out
Hope it's not too serious.
Shit, my wife had it because she had a blood clot a few years ago.
I was out for 36 hours after my first dose. Apparently the side effects are meant to be worse after the second dose. Due for mine in April. I think I might just preemptively tell the hospital I won't be in for two days
Really makes you think about just how awful getting actual Covid might feel.
I work for a nursing home group and we have had all our homes vaccinated and all reports are that the first AZ jab had much worse side effects than second.
Not with the AZ but I had the Pfizer jab and felt like that. It’s just the body immune system kicking in. My brother was the same for a day. But next day was absolutely fine. I had mine while I was at work as well on a night shift. Had my second about 3 weeks ago and had no effects at all.
Maybe I'm just stating the obvious here, in which case I apologise, but this is how they explained it:
"The effectiveness varied when researchers tested the vaccine in other countries, where variants of the coronavirus are circulating. In Latin America, where the variant P.1 has cropped up, the vaccine was found to be 66 percent effective. In studies in South Africa, where a variant called B.1.351 is circulating, effectiveness was lower: 64 percent.
But the numbers don't tell the whole story.
When researchers looked specifically at the vaccine's protection against the most severe forms of illness, effectiveness shot up to 86 percent.
And it prevented 100 percent of hospitalizations and deaths related to Covid-19. No one who got the Johnson & Johnson shot was hospitalized or died of Covid-19 during the study's follow-up period of 28 days after vaccination."
https://www.nbcnews.com/health/health-news/how-effective-johnson-johnson-vaccine-what-know-n1259652
Single dose, can be stored for three months at the temperature of a regular fridge, sounds very promising all together.
Thanks, that’s very helpful and reassuring!
I have seen this reported/posted a few times.. Is that supposed to be very impressive? how does it compare to the other vaccines..
Aren't most of the people in the trial not in the highest risk category? If they wait for around 160-200 cases to publish their data, even if they had ~30 people who got the vaccine and got infected, the odds of someone dying isnt that high..
Or are they reporting from a much larger sample size?
It’s similar for all vaccines. And it’s a claim you take with a pinch of salt. The stats are powered to show a difference based on their primary endpoint, which is symptomatic cases for most of them and mod-severe covid fo J&J. The analyses were triggered when there were enough cases to show a statistically significant difference between drug and placebo.
The numbers of deaths/hospitalisations will have been much lower so not yet reached statistical significance i.e. difference between drug and placebo could be down to chance. The trends are definitely encouraging but we need more data to be certain about claims like that.
Basically, your concerns about numbers/sample size are correct.
Mother in law got the AZ vaccine without any issues, but she only had it once. Will make a note if she reacts after second dosage.
Good question (I see Pogue has already answered it) and maybe the bolded part was way too suggestive or flat out misleading, frankly I have no idea at all. Just that it sounded quite promising in combination with the protection against severe forms of illness being in the high eighties, and after reading up how the vaccin was developed and what it tries to do/how it's supposed to work. I read that J&J were planning to produce a billion doses in 2021, again no idea if they can actually deliver on that scale without logistical problems arising, but it definitely makes me more hopeful there can be some significant improvement on a global scale over the next 6-8 months.