I’m no scientist and really don’t know if this right. But with viral load being possibly a case, would wearing a mask that you’ve contaminated accidentally with covid19 increase the viral load if you’re just walking around with it Stuck to the front of your face constantly breathing it in?
SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)
- Thread starter Don't Kill Bill
- Start date
Not really. The second french clinical test independent from Raoult has shown that most patients don't react to plaquenil+azythromycin and a chinese clinical trial goes in the same direction. Also the argument doesn't actually work when Sanofi, the ones owning plaquenil, increased the production of plaquenil, if anything we should look at the links between Raoult and Sanofi. Angers CHU started a new clinical trial that is supposed to be less amateurish and much larger with 1300 patients. Below you have a researcher from the CNRS explaining where the problem lies with Raoult and his experiment, basically he botched everything.
I'm sorry but if there was an evidence-based way of treating this it would be given. We are considering everything. All options are being carefully considered. I haven't heard a single one of my colleagues worried about pharmaceutical companies or "pressure" of any sort. Heck I'd give homeopathy if it meant curing COVID-19.
Doctors are independently minded individuals. And we are science based, but we need to consider if giving medications that can potentiate cardiac abnormalities and liver derangement is worth giving based on a small poorly designed study with no useful end points with other studies showing conflicting data.
Plural of anecdote is not data.
Second clinical trial was also not a random test as well. There has been few other test were subjects were immunocompromised and they concluded it doesn't work. It seems like there is an eagerness to prove it doesn't work. French doctors published another test in which they claimed it cured 78/80 patients and recovery time was 6 days which is way less than what it is now. This was also not randomised.
There is a reason why this has been included in WHO trial. We should wait for their result. India, which is the world largest producer, have recommended it for high risk category people only for now.
Neither am I, it's just common sense that if cough = droplets, than any sort of barrier will help.
Plus, if you're a covid positif the mask isn't mean to help you, it's mean to help the others.
It's like a mouth gag, it's meant to stop you, not shielding you from others. You're the assumed monster, not the victims.
Anti-parasitics have never shown any potential as anti-virals in any significant "in vivo" studies that I know. Neurotoxicity is also a concern at higher doses I'd imagine for it do have the kind of antiviral effects seen in the lab.
I wouldn't personally be excited about its potential as a candidate but who knows how it'll do in human trials, right now we'd take anything.
Update in Ireland:
The second trial that you are talking about is from the same doctor who claimed that 65/80 had positive results, none of his work is reliable. There is an actual clinical trial that has been started in Angers including 1300 patients though, we will have a better idea about plaquenil when we have those results.
Couldn't agree more. I am desperate for a sight of good news. Spending unhealthy hours on various sites learning about various drugs and virus and I am an engineer. Hopefully we find something that works.
Thats a little scary, but also good news if it means Irland been able to keep the virus away from the elders.
The promising part in this is that it is already human-approved. But the actual result it has agains Covid can turn out to be pretty meaningless. Many times things in cell culture don't replicate in a body.
The silver lining is that our earth seems to be healing at a very magical pace, 1-2 months of us slowing down really gets our earth going. Been reading alot of good stuffs happening on that front, maybe that'll cheer you up abit
It did. Saw a picture in which Himalayas were visible from one city in North India which wasn't possible earlier and it looks stunning. But I want to be able to go there and see it myself
.We will feck it up again really quickly when given the chance.
For what its worth I'm sure we will. It's the lives lost and impact that has on families until that point that is what is so demoralising
But we'll get onto the right combination that'll lower mortality rate for our inpatient cohort, I don't think it'll be existing medications. But I think the usual sort of things that make delay vaccine going into bypass I think (hope) will be bypassed, with a few risks, but worth taking.
Right now I think trials are fine. Whether it be hydroxychloroquine, azithromycin, BCG, vitamin D etc but its important to highlight that we know what does work, that's preventing people getting sick in the first place.
Healthcare worker PPE, social isolation, social distancing, forensic contact tracing and testing, all of which our government has screwed up amounting to clinical and borderline criminal negligence in my opinion. Had they taken the relevant steps and not listened to behavioural psychologists or politics or whatever their initial strategy was we would have trended more towards a flattened curve earlier.
Unfortunately that’s not the case. There has been clusters of the virus in about 13 nursing homes around the country.
Thats sucks man. Same here in Sweden.
This whole situation is horrible.
I almost feel nothing anymore when i read things like ”1000 people dead in 24 hours” And i scare myself a little when the only comfort i can come up with is that most of them was on the last page anyway. Its a dangerous though and feeling to feel so numb to people dying.
Not so surprising given we’ve the youngest population in Europe (or is it just Western Europe?). We’re at the opposite end of the scale from Italy in those terms.
This is an example of that. Those poor people.
https://www.google.com/url?sa=t&sou...DMAZ6BAgJEB0&usg=AOvVaw1daWCS6M4eJMuvIYHggIh7
There are news that Turkey blocked a cargo plane headed for Spain, which stopped there, with ventilators and protective material (already paid for).
J&J already announced they won't be making any profit from a potential vaccine.
Here in Azores, São Miguel island has been seen from Terceira island several times in the last few days. This was a rare event that happened every few years.It did. Saw a picture in which Himalayas were visible from one city in North India which wasn't possible earlier and it looks stunning. But I want to be able to go there and see it myself
It was 4ish in the morning, I was going to bed.
Honestly he's such a loose cannon that he'll even screw up big pharma companies so he can tweet he saved the world on his own. And he may actually be right this time. For all the wrong reasons obviously.
Trump is not the hero I want in the world right now. But he's the hero I need.
What do you make of this British mob testing Siltuximab (aka Sylvant) in Italy? Seems like in principle in might help? It binds to IL-6 cytokines and is hoped to therefore reduce lung inflamation.
I'm glad talk is now turning towards an immediate treatment of the symptoms (rather than or including vaccine discussions). Worth a thread of its own or just keep it in here?
I've been trying to read as many articles daily on progress of potential cures (there are quite a few). But speed is of the essence as human trials take time and this is where Trump ironically may tell Fauci to cut the crap and go with the best results before America's death rate worsens in the red states (screw NY and California). There are some large human trials by WHO for which an update is imminent in mid-late April for efficacy.
Biologics should make in theory for very effective agents
The aetiology of the most severe manifestation of COVID19 is ARDS which is underpinned by cytokine storm so agents targeting that should definitely be considered in reducing mortality and morbidity
https://www.cancernetwork.com/news/...clinical-trial-tocilizumab-covid-19-pneumonia
Tocilizumab is another good shout
This NHK World report has been doing the rounds on Whatsapp.
Not sure if it's already been posted but Trump is at it too, blocking shipments of PPE to Germany. We have to be careful a war doesnt come out of all this.
A while ago it was revealed that Sweden was holding truckloads of protective equipment at the border with Norway for days, over some EU directive about exporting such equipment in these times. It was eventually sorted out though, at least temporarily.
Been posted earlier. The experiment shows reasonable information. The video has some factual errors and the simulation should be taken with a pinch of salt, until you know how they carried out the simulation.
They did it to France as well as Germany.
It also doesn't show what happens when people cough into tissues or their hands. I'd like to see how much both things reduce the droplets in the air.
@Enigma_87 was absolutely spot on earlier in this thread about masks. He said exactly what I was told from someone in the NHS.
In the EU anyway, I think.
The paper is a reasonable start but doesn't provide anything definitive. For example, it says the virus survives* in droplets for the duration of the experiment. That only gives a lower limit for its surviability. At least when I read it, they didn't seem to give the proper material names, nor the surface conditions. The former is important because you can have different grades of stainless steel and obviously you can get a variety of different plastic. The fact the virus has different survival rates on different surfaces suggests surface conditions are important. Yet they've not provided us with any information about the characteristics of these surfaces. At least in droplet impact studies, you normally expect a description of the surface such as its surface roughness, whether it is wet, heated etc. So its a good start, but unfortunately the media have also blown the paper out of proportion.
*Something I would like to know about that paper is what does it actually mean by virus stability and survivability and what actually influences those factors? Is it the rate at which liquid from the surface is evapourated or something else? I don't understand this part.
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Seems its widespread unfortunately . i posted a story earlier of france blocking shipments to us as early as march 3rd . America in turn have hi jacked various deliveries to different countries . Hope this can be stamped out but it seems as though its like the wild west out there in regards to how countries ( and companies for that matter ) are acting . As i mentioned earlier i hope this doesnt happen once a vaccine is found
Oy vey...
https://thehill.com/homenews/state-...7jmy14AQymRNJRh6Pcx76KjH5G2lne7sBLk4h5pmyJ_08
Officials in Montgomery County, Ala., say that thousands of medical masks the county received from the national stockpile last week were rotten and expired.
Local emergency management director Christi Thornton said the package of 5,880 procedure masks was ruined because they had dry rot, The Associated Press reported.
The face covers reportedly had a 2010 expiration date.
https://thehill.com/homenews/state-...7jmy14AQymRNJRh6Pcx76KjH5G2lne7sBLk4h5pmyJ_08
Officials in Montgomery County, Ala., say that thousands of medical masks the county received from the national stockpile last week were rotten and expired.
Local emergency management director Christi Thornton said the package of 5,880 procedure masks was ruined because they had dry rot, The Associated Press reported.
The face covers reportedly had a 2010 expiration date.
From what others have said, any vaccine is a long way off, so I wouldn't worry about it just yet!