SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

If over a million people have tested positive Covid-19 in UK, what's the best estimate for the overall number who have caught it?

I know we aren't going to be anywhere near herd immunity levels yet, but if we have a bad Winter it might get up to that.
 
If over a million people have tested positive Covid-19 in UK, what's the best estimate for the overall number who have caught it?

I know we aren't going to be anywhere near herd immunity levels yet, but if we have a bad Winter it might get up to that.
Your not going to get herd immunity in 1or 2 waves no matter how bad the winter is and if ye did the NHS would probably implode.
 
@acnumber9 I think this is the best explanation for why there has been a rise, from someone who understands epidemiology in a way we never could. There's a tendency to look for a particular pattern at a particular place at a particular moment in time that explains why something has happened. But the trends are more general and the timing and locations are more random than we want to believe. Randomness in this situation is unfair and unsettling so we look to identify order in situations where there really isn't much.
To be honest, it seems to all be guesswork. In my country (South Africa), nothing is making sense. We decided to ease lockdown restrictions when cases started rising, yet our case numbers have remained relatively level. Granted we don’t have the capacity to do lots of testing, but anecdotally the hospitals are much emptier. Maybe it has to do with summer, but I have a feeling the densely populated poorer areas were unable to stick to the strict lockdown requirements, resulting in an effective herd immunity for the majority of the population.
 
Can't share the image, but from PHE pie chart, the following "Sites of multiple outbreaks for the last 4 weeks";

Hospitality 4%
Hospitals 4%
Workplace 20%
Care homes 26%
Education 36%
Other 10%
So shutting schools and non essential work for say 4 (2 of which could have been half term so really only 2 weeks) could have cut outbreaks by 50 percent?

Dithering Johnson at it again
 
Your not going to get herd immunity in 1or 2 waves no matter how bad the winter is and if ye did the NHS would probably implode.

Was estimated about 8% had it before, we could be 10% now and maybe 16% after a bad winter. 10% is only 6.7 million.
 
To be honest, it seems to all be guesswork. In my country (South Africa), nothing is making sense. We decided to ease lockdown restrictions when cases started rising, yet our case numbers have remained relatively level. Granted we don’t have the capacity to do lots of testing, but anecdotally the hospitals are much emptier. Maybe it has to do with summer, but I have a feeling the densely populated poorer areas were unable to stick to the strict lockdown requirements, resulting in an effective herd immunity for the majority of the population.

Vitamin d levels, direct sun, more outdoorsy culture, different age profile, more exposure to similar pathogens from the past, variations in genealogy, definitely lots of things that can mediate the impact of the virus. But herd immunity could only have happened if at least 60% of the population got infected. There's over 5m people 65+ in south africa nearly 20m that are 45-64. Unless a million or more people have died from something we thought wasn't covid, it's hard to make that argument work.

There are lots of things we don't know and it's useful to recognise that, but that doesn't mean we don't know anything. We know it kills older people at a notably high rate, a rate that we couldn't possibly not notice.

The point Osterholm is making is that just because you only see embers now doesn't mean you've controlled the fire, it's just waiting on that one relatively random spark that lights at exactly the right time, and its neighbours are in a urine condition to spread it. The chances that there will be another spike in South Africa are very high, and when they do, it won't be all that helpful to find out what that one spark was. The problem is the number of embers ready to burst, and the combustible nature of the underlying components.

So shutting schools and non essential work for say 4 (2 of which could have been half term so really only 2 weeks) could have cut outbreaks by 50 percent?

Dithering Johnson at it again

No that is not how PHE want you to interpret their data.
 
Vitamin d levels, direct sun, more outdoorsy culture, different age profile, more exposure to similar pathogens from the past, variations in genealogy, definitely lots of things that can mediate the impact of the virus. But herd immunity could only have happened if at least 60% of the population got infected. There's over 5m people 65+ in south africa nearly 20m that are 45-64. Unless a million or more people have died from something we thought wasn't covid, it's hard to make that argument work.

There are lots of things we don't know and it's useful to recognise that, but that doesn't mean we don't know anything. We know it kills older people at a notably high rate, a rate that we couldn't possibly not notice.

The point Osterholm is making is that just because you only see embers now doesn't mean you've controlled the fire, it's just waiting on that one relatively random spark that lights at exactly the right time, and its neighbours are in a urine condition to spread it. The chances that there will be another spike in South Africa are very high, and when they do, it won't be all that helpful to find out what that one spark was. The problem is the number of embers ready to burst, and the combustible nature of the underlying components.



No that is not how PHE want you to interpret their data.
Yes all good points. Apparently there may have been a coronavirus that went around here several years ago too. Also, there is significant work done on TB (everyone has to be vaccinated). Unfortunately a second spike is likely, but people have been going out (with masks) and working as if it's all back to normal for a month or two with no significant change in case numbers.
We have a bigger issue than developed countries - when that second spike happens, we can't afford another hard lockdown. We will have more people dying from hunger than covid-19. I've also heard that 12% of countries (obviously the wealthy Western nations) have already purchased over 50% of the vaccines, so looks like dark days ahead for a lot of us.
 
Definitely a different spin on the story than the one put out by the government earlier this week that they were lowering the threshold because of recent improvements in software capabilities that allow them to be more precise than even the original target
 
@acnumber9 I think this is the best explanation for why there has been a rise, from someone who understands epidemiology in a way we never could. There's a tendency to look for a particular pattern at a particular place at a particular moment in time that explains why something has happened. But the trends are more general and the timing and locations are more random than we want to believe. Randomness in this situation is unfair and unsettling so we look to identify order in situations where there really isn't much.
And as I said before. For every expert that says one thing, there’s one that says another.

https://www.google.co.uk/amp/s/amp....number-rise-if-secondary-schools-fully-reopen

Depends on what you want to believe. Meanwhile what we have our facts. And PHE shows that educational settings have had more outbreaks than anywhere else.

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/923668/Weekly_COVID19_Surveillance_Report_week_40.pdf
 
And as I said before. For every expert that says one thing, there’s one that says another.

https://www.google.co.uk/amp/s/amp....number-rise-if-secondary-schools-fully-reopen

Depends on what you want to believe. Meanwhile what we have our facts. And PHE shows that educational settings have had more outbreaks than anywhere else.

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/923668/Weekly_COVID19_Surveillance_Report_week_40.pdf

Oh, good. We're back to trusting facts, and you've chosen a source to believe. Let's go with that one. In the document you've cited, young kids have fewer infections than any other age group. Yet they're the source of most of the outbreaks. Can you explain how they fit together? Alternatively, one of us is misrepresenting the evidence. The facts speak for themselves, supposedly, so it should be easy to explain.
 
Oh, good. We're back to trusting facts, and you've chosen a source to believe. Let's go with that one. In the document you've cited, young kids have fewer infections than any other age group. Yet they're the source of most of the outbreaks. Can you explain how they fit together? Alternatively, one of us is misrepresenting the evidence. The facts speak for themselves, supposedly, so it should be easy to explain.
As you’ve said yourself kids are impacted by the virus differently for reasons we don’t understand. They may be less likely to show symptoms and therefore less likely to be tested could they not? I’ve linked a epidemiologist who said opening secondary schools with no restrictions could cause increases, that goes with the case numbers.

I see you’re now citing the evidence used in our circuit breaker in Northern Ireland. You say that for face masks a 0.2 reduction in the R rate is significant. Yet for some reason are arguing against the fact that schools are a significant contributor despite it having a greater impact on the R rate from the exact same evidence. Not only are you picking and choosing which epidemiologists to believe, you’re choosing what parts of the same evidence to believe.

I don’t really want another day of back and forth on this. We just fundamentally disagree on the subject. Due to the fact that schools just aren’t going to close I hope for everybody’s sake that you are right.
 
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It’s beyond me why I’ve gone to Lidl and there’s long queues, people stockpiling etc. when BJ made it a point to say that essential supermarkets will NOT be closing
 
It’s beyond me why I’ve gone to Lidl and there’s long queues, people stockpiling etc. when BJ made it a point to say that essential supermarkets will NOT be closing

you’re surprised? The past 5 years with Brexit, elections and Covid-19 has done more to teach me about how many fecking morons there are in the world than anything else ever will.
 
We'll 100% be released for Christmas.

Politics says it will happen

Think it will be similar to summer. 4 weeks are up and they'll slap another 2-3 weeks on as cases not coming down enough....e.g R level not below 1 and then miraculously will go back to tier 3 restrictions for the week around xmas (although pubs will surely remain shut). Then cases will go up and go back to lockdown/circuit breaker for first few weeks of January.

Would love to be wrong but can't see anything but that scenario playing out.
 
Was estimated about 8% had it before, we could be 10% now and maybe 16% after a bad winter. 10% is only 6.7 million.

I still believe it's much higher than that with all the cases missed.

Of course not quite a guarentee they'll even be immunity given the odd re-infection reported across the world.
 
If over a million people have tested positive Covid-19 in UK, what's the best estimate for the overall number who have caught it?

I know we aren't going to be anywhere near herd immunity levels yet, but if we have a bad Winter it might get up to that.

I listened to a podcast where an epidemiologist did a rough estimate on what it would it take to reach herd immunity without a vaccine. They figured at least 5 or 6 waves.
 
As you’ve said yourself kids are impacted by the virus differently for reasons we don’t understand. They may be less likely to show symptoms and therefore less likely to be tested could they not? I’ve linked a epidemiologist who said opening secondary schools with no restrictions could cause increases, that goes with the case numbers.

I see you’re now citing the evidence used in our circuit breaker in Northern Ireland. You say that for face masks a 0.2 reduction in the R rate is significant. Yet for some reason are arguing against the fact that schools are a significant contributor despite it having a greater impact on the R rate from the exact same evidence. Not only are you picking and choosing which epidemiologists to believe, you’re choosing what parts of the same evidence to believe.

I don’t really want another day of back and forth on this. We just fundamentally disagree on the subject. Due to the fact that schools just aren’t going to close I hope for everybody’s sake that you are right.

Yeah, it could be a cause of them having few or no symptoms making them less likely to fall into pillar 1 and pillar 2 testing. But if you accept the premise that they have fewer symptoms, then that's another reason why kids spread it less: asymptomatic people can spread it, but much less often. Symptoms don't play a role in the random sample swab study ran by the ONS, though. And it has consistently shown young kids are infected much less frequently than young adults, and that young kids have consistently tested positive less often than someone my age, even while the majority of us are not going into work every day while they go into school every day.

I'm not picking and choosing evidence nor epidemiologists. That's a weird case of projection. I used the evidence you provided on Northern Ireland, just like I used the evidence @F-Red provided from PHE, and in both cases I outlined the weaknesses in the data that could lead to the wrong conclusion while using that data to make a point. I've spent a lot of these discussions just assessing the evidence, never dismissing it. I have never said "well one expert says this and the other expert says this so really it's all about opinions, right?". I believe it's important to consider all of the evidence and evaluate it on its strengths and weaknesses, with the objective of better understanding the situation, while you use it as a tool to prove a point. So let's break down those two claims seperately.

Yes I think a reduction of 0.2 is significant for masks. I also think a reduction of 0.2 for schools is significant too. If you actually asked people what they thought rather than using them as a prop to tell other people why they're stupid, you might run into this confusion less often. As laid out in NI's documents, it's not just about the impact it has on reducing transmission, but also the economic, social and psychological impacts. This is their assessment of school closures:

"Non-COVID impact (incl. social and psychological; excl. economic): High. Disruption of education, wellbeing of children. Increases in domestic abuse, home accidents, and reductions in child and adult mental health. Likely to have a higher adverse impact (education, physical and mental well-being) on vulnerable children and low income and BAME communities."

Alternatively they assess the impact of closing classes when cases pop up - the method they're going back to now - as "low". They also assess the impact of wearing masks as "low", regardless of whether it's indoors or outdoors.

That's quite a big distinction to start with. Wearing masks hurts basically nobody, but it reduces the impact of transmission signficantly. Closing schools hurts a shitload of people, but it reduces the impact of transmission significantly. How significantly does it have to reduce transmission for those other harms to be worthwhile? That isn't self-evident.

Personally, I think if they believe closing schools could reduce the R rate by as much as 0.5, they should close schools. The problem is, they've said themselves they have low confidence in that assessment, and have outlined the fundamental issue which is they don't know how infectious kids are. For whatever reason you keep skipping past that main point, you choose to believe these scientific advisers about one thing, but not the other. I choose to believe them about all of these things, while recognising the level of uncertainty that comes with their assessments that they themselves state over and over again.

Irrespective of my opinion, I don't think people are stupid for thinking that schools should stay open even if it did reduce the R rate by 0.5. It's a very complicated problem. The evidence you provided outlines the harm it will do, and they have high confidence in that assessment.

Secondly, the claim the epidemiologist made is completely consistent with the other scientific evidence provided. First he specifies secondary schools, not primary schools, and second he points out the need for some restrictions. No-one is saying that if you have secondary schools completely open with no measures that it will have no impact on transmission. Every country has applied some measures because they (and the scientific community) agree that it does relatively little harm to apply these measures, while it does have an impact on transmission.

If he tightened that definition of "secondary schools" to "people 16+" then his argument would be right there in the middle of the scientific consensus, which is very different from what you, @Garethw, @golden_blunder or others have stated. They were talking about young kids specifically, you were talking about young kids inclusively. That epidemiologist is not, because he's looked at the evidence.

So let's be clear about the position stated. The evidence strongly suggests that primary schools are not hotspots for the virus, but leaving them open will have a small impact on transmission. The evidence is less clear on young teenagers, but they do get infected more often, so they are likely to spread it more often. The evidence is clearer on older teenagers, who get infected much more often than young kids, and they have led the surge in cases along with university age students.

Overall, closing schools would reduce the transmission rate. It probably wouldn't reduce the transmission rate enough for it to be worthwhile closing primary schools. It might not reduce the transmission rate enough among kids 10-15, and there is an open question about whether they're getting it in schools or bringing it into schools, and how much they pass it among each other. It definitely would reduce the transmission rate enough for it to be worthwhile closing school for 16-18 year olds, and even more so for uni students. But they're political decisions.

My argument to you or others has never been that we shouldn't close schools. I don't think closing schools is the catastrophe others do, and if it's a trade-off between this and many other restrictions, then the economic harm done to low-income parents in this jobs that are disproprortionately effected by restrictions might well do more harm to their kids than closing the schools. If they don't have food to eat they don't learn. So at the very least I think cloing schools should be on the table. But it isn't a silver bullet, nor an explanation for us being where we are now.

What I've been arguing against is your explanation for why we should close schools. The notion that it's obvious young kids going back to school is the driver of this trend...it's not obvious, and if you test that theory in a number of contexts, a number of flaws pop up. We shouldn't be making these kinds of decisions or having these kinds of discussions on misrepresentation of the data, or dismissal of the best available evidence, just because anyone that doesn't think your way is an idiot. That's dangerous in many ways. So when you made arguments that said "the evidence says this" or "one epidemiologist says this, others say this, it's up to you who to believe", I thought it worth disputing those claims with actual evidence.
 
Yeah, it could be a cause of them having few or no symptoms making them less likely to fall into pillar 1 and pillar 2 testing. But if you accept the premise that they have fewer symptoms, then that's another reason why kids spread it less: asymptomatic people can spread it, but much less often. Symptoms don't play a role in the random sample swab study ran by the ONS, though. And it has consistently shown young kids are infected much less frequently than young adults, and that young kids have consistently tested positive less often than someone my age, even while the majority of us are not going into work every day while they go into school every day.

I'm not picking and choosing evidence nor epidemiologists. That's a weird case of projection. I used the evidence you provided on Northern Ireland, just like I used the evidence @F-Red provided from PHE, and in both cases I outlined the weaknesses in the data that could lead to the wrong conclusion while using that data to make a point. I've spent a lot of these discussions just assessing the evidence, never dismissing it. I have never said "well one expert says this and the other expert says this so really it's all about opinions, right?". I believe it's important to consider all of the evidence and evaluate it on its strengths and weaknesses, with the objective of better understanding the situation, while you use it as a tool to prove a point. So let's break down those two claims seperately.

Yes I think a reduction of 0.2 is significant for masks. I also think a reduction of 0.2 for schools is significant too. If you actually asked people what they thought rather than using them as a prop to tell other people why they're stupid, you might run into this confusion less often. As laid out in NI's documents, it's not just about the impact it has on reducing transmission, but also the economic, social and psychological impacts. This is their assessment of school closures:



Alternatively they assess the impact of closing classes when cases pop up - the method they're going back to now - as "low". They also assess the impact of wearing masks as "low", regardless of whether it's indoors or outdoors.

That's quite a big distinction to start with. Wearing masks hurts basically nobody, but it reduces the impact of transmission signficantly. Closing schools hurts a shitload of people, but it reduces the impact of transmission significantly. How significantly does it have to reduce transmission for those other harms to be worthwhile? That isn't self-evident.

Personally, I think if they believe closing schools could reduce the R rate by as much as 0.5, they should close schools. The problem is, they've said themselves they have low confidence in that assessment, and have outlined the fundamental issue which is they don't know how infectious kids are. For whatever reason you keep skipping past that main point, you choose to believe these scientific advisers about one thing, but not the other. I choose to believe them about all of these things, while recognising the level of uncertainty that comes with their assessments that they themselves state over and over again.

Irrespective of my opinion, I don't think people are stupid for thinking that schools should stay open even if it did reduce the R rate by 0.5. It's a very complicated problem. The evidence you provided outlines the harm it will do, and they have high confidence in that assessment.

Secondly, the claim the epidemiologist made is completely consistent with the other scientific evidence provided. First he specifies secondary schools, not primary schools, and second he points out the need for some restrictions. No-one is saying that if you have secondary schools completely open with no measures that it will have no impact on transmission. Every country has applied some measures because they (and the scientific community) agree that it does relatively little harm to apply these measures, while it does have an impact on transmission.

If he tightened that definition of "secondary schools" to "people 16+" then his argument would be right there in the middle of the scientific consensus, which is very different from what you, @Garethw, @golden_blunder or others have stated. They were talking about young kids specifically, you were talking about young kids inclusively. That epidemiologist is not, because he's looked at the evidence.

So let's be clear about the position stated. The evidence strongly suggests that primary schools are not hotspots for the virus, but leaving them open will have a small impact on transmission. The evidence is less clear on young teenagers, but they do get infected more often, so they are likely to spread it more often. The evidence is clearer on older teenagers, who get infected much more often than young kids, and they have led the surge in cases along with university age students.

Overall, closing schools would reduce the transmission rate. It probably wouldn't reduce the transmission rate enough for it to be worthwhile closing primary schools. It might not reduce the transmission rate enough among kids 10-15, and there is an open question about whether they're getting it in schools or bringing it into schools, and how much they pass it among each other. It definitely would reduce the transmission rate enough for it to be worthwhile closing school for 16-18 year olds, and even more so for uni students. But they're political decisions.

My argument to you or others has never been that we shouldn't close schools. I don't think closing schools is the catastrophe others do, and if it's a trade-off between this and many other restrictions, then the economic harm done to low-income parents in this jobs that are disproprortionately effected by restrictions might well do more harm to their kids than closing the schools. If they don't have food to eat they don't learn. So at the very least I think cloing schools should be on the table. But it isn't a silver bullet, nor an explanation for us being where we are now.

What I've been arguing against is your explanation for why we should close schools. The notion that it's obvious young kids going back to school is the driver of this trend...it's not obvious, and if you test that theory in a number of contexts, a number of flaws pop up. We shouldn't be making these kinds of decisions or having these kinds of discussions on misrepresentation of the data, or dismissal of the best available evidence, just because anyone that doesn't think your way is an idiot. That's dangerous in many ways. So when you made arguments that said "the evidence says this" or "one epidemiologist says this, others say this, it's up to you who to believe", I thought it worth disputing those claims with actual evidence.
Once again I’m lost in a sea of words. Being concise is still a virtue. We disagree. You’re still claiming you’re providing actual evidence when you aren’t. You’re providing different theories and incorrect numbers. There’s nothing more for me to say.

I choose not to believe them on some things like school closures because they’ve already lied to us about face masks when it suited the political agenda and the case numbers staring us right in the face. The only way to test is to close schools and see what happens. Or at least consider staggering attendance.
 
Once again I’m lost in a sea of words. Being concise is still a virtue. We disagree. You’re still claiming you’re providing actual evidence when you aren’t. You’re providing different theories and incorrect numbers. There’s nothing more for me to say.

I choose not to believe them on some things like school closures because they’ve already lied to us about face masks when it suited the political agenda and the case numbers staring us right in the face. The only way to test is to close schools and see what happens. Or at least consider staggering attendance.

Or the opposite. Which we're doing. Keep schools open and bring things under control anyway, like Ireland now, or the other countries we've already discussed. England have already seen the rate fall by 0.2 in the last two weeks with less strict measures outside schools. They just need to see a continuation of that to see cases level off and eventually begin to fall.
 
Or the opposite. Which we're doing. Keep schools open and bring things under control anyway, like Ireland now, or the other countries we've already discussed. England have already seen the rate fall by 0.2 in the last two weeks with less strict measures outside schools. They just need to see a continuation of that to see cases level off and eventually begin to fall.
Like I said, I hope you’re right and it works. Unlike the local lockdowns.
 
Like I said, I hope you’re right and it works. Unlike the local lockdowns.

Fair enough, we agree on that! And on the point about brevity. Never has been something I've got the hang of, despite my appreciation of it. But when I use fewer words you read into what I've said and accuse me of things I've never even thought!
 
Police say they were attacked as they tried to break up an illegal rave at a warehouse near Bristol.

Officers who were called to Yate at around 22:30 GMT on Saturday said up to 700 people were in attendance.
Some of the crowd began acting violently towards officers as they were told to leave, Avon and Somerset Police said.
The crowd was ordered to disperse and police said two people were in custody.

https://www.bbc.co.uk/news/uk-england-bristol-54769055

What is wrong with people??
 
https://www.google.co.uk/amp/s/uk.mobile.reuters.com/article/amp/idUSKBN27H1BD

Government hitting the panic button fully and trying to speed up review data on the Oxford vaccine. Coupled with the apparent leaked plans to mass vaccinate Scotland in 6 weeks time, we know that this is headed towards a rushed approval. Wonder how they are going to increase confidence enough for significant uptake.

For once I don't think this is a sign of the government panicking or making it up as they go along, it just reflects how many people are now involved in the Astra trial and how long ago they were given the vaccine.

The trials by all the vaccine makers are (to put it crudely) just waiting for enough of the trial participants to catch covid. Once they've got enough covid cases they can compare the placebo group to the vaccine group and decide if there's anything statistically significant going on. In the ideal world the only ones who catch covid will have taken the placebo. More likely though is we hear news that "fewer" people catch it or that the ones who catch it are less ill if they took the vaccine.

Normally the regulators wait until the companies are ready to present their final trial report - this time they're going to start looking at the data in parallel with Astra's own researchers. In principle at least that will potentially speed the approval process, because if it comes down to "need more covid cases" to confirm the statistics they can give approval for adding more people to the trial. They can even give permission for the placebo group to get the vaccine if the numbers are obvious, and give permission for adopting the idea that the comparison group is another chunk of the general population rather than those given a placebo.

The European Medical Agency had already decided on that approach a few weeks back.
European Medicines Agency have started a rolling review of astrazenca's covid19 vaccine in order to quicken the process
https://www.ema.europa.eu/en/news/ema-starts-first-rolling-review-covid-19-vaccine-eu
 
Back to having nothing to look forward to in free time again for another 2 months or so then potentially. What an absolute shit situation this is. Done with it.
 
Back to having nothing to look forward to in free time again for another 2 months or so then potentially. What an absolute shit situation this is. Done with it.

Is not getting through this difficult time with you and your family being safe enough to look forward to?
 
My test and trace has updated and told me to isolate for 9 days. I've told my boss and they either think I'm lying or I've been coming to work for the past 5 days knowingly.

Any idea why it's told me to isolate for 9 days and not 14?
 
If over a million people have tested positive Covid-19 in UK, what's the best estimate for the overall number who have caught it?

I know we aren't going to be anywhere near herd immunity levels yet, but if we have a bad Winter it might get up to that.

Herd immunity may well require in excess of 50 million people to be infected or vaccinated.
 
My test and trace has updated and told me to isolate for 9 days. I've told my boss and they either think I'm lying or I've been coming to work for the past 5 days knowingly.

Any idea why it's told me to isolate for 9 days and not 14?
Just send him a pic of it?