I've not argued it won't be a disaster because I don't know for sure but I do believe we are a big enough economy and a smart enough country to cope with whatever we do.
Last time: I voted remain because I work for a part of one of the biggest scientific companies in the world. The sector I work in (Agricultural research) conducts trials all over the world. I work very closely with colleagues in France, Spain, Germany, Italy, Romania, Poland, Greece, Italy and so on. I was concerned about what impact it would have on the UK branch of this company and still am. So far it has had no impact and there seems to be no mad panic at managment level but IF there was a second referendum, I would vote the same way.
So far it hasn't undermined client confidence but I do worry, of course I do.