I don't think Cruz will stand a chance. His chance was this year when the anti-establishment sentiment was at its highest, if Trump gets elected and succeeds in his first term, that makes him a better maverick than Teddy, if it goes poorly the audience would defect to the establishment. I also think a stronger nominee like Paul Ryan will come into play by then. Basically Cruz got out crazied by The Don.
Normally i would agree, but he and Rubio are the young guns in the GOP and they are highly adaptable and will learn from their experience and be back. If Trump is President going into the next election cycle, he will have probably made a massive mess of things and get challenged by a GOP candidate in 4 years.