Before Fellaini injury I predicted 3-5-2. One of the key points is to have a midfield trio. But now with all of Fellaini, Pogba and Carrick (fitness issue, lack of game time) likely to be out, I have no idea.
I think now Jose has two options with regards to the midfield
1. Midfield trio by playing Carrick (if ready) or someone off position like Blind/Tuanzebe there, who knows, Jose has done it before @ other teams
2. Midfield duo in a 3-4-3 like someone has suggested here. One bright spot is that we did well against CSKA
I think it's a close call. But I'm gonna go with 3-4-3, with both Matic and Herrera mainly tasked with defending/ball control instead of being more offensive, and wingers and wingbacks likely to help defending/combating the midfield, acting as the "3rd" midfielder. Also, wingbacks likely to drop deeper as compared to 3-5-2.
----------------Lukaku------------------
----Rashford---------------Mkhi--------
Young----Matic----Herrera----Valencia
-----Jones----Smalling----Bailly--------
Rashford, Mkhi and Martial are close call @ winger position. Not surprised to see Martial there. I would love to see both Rashford and Martial, and us playing 7-0-3 pure counter attacking !