I presume the latter.
The vaccines | vaxxed boosted unvaxxed? New poll
- Thread starter Badunk
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I presume the latter.
Can someone explain this to me in layman terms? Does the J&J work against the SA variant?
Yes. It seems to. Although takes a month or so to give you any protection.
Good Twitter thread on latest AZ drama.
Thank you
I am not making that comparison.
I am talking more generally. That data will show vaccinated people will not be infectious. That's the path to us (mankind) returning to previous ways, once everyone is vaccinated (all over the world, or in your specific region with only vaccinated people allowed to come in)
Probably mentioned already but an article also discusses some other issues about deciding "which is best":
https://www.nature.com/articles/d41586-021-00409-0
What really blows my mind is that the more recent results, the ones they should have released, were still good!
It is pretty amazing how poorly run company AZ is.
Is it still 100% effective against hospitalisations/severe disease or was that also an exaggeration?
The people running the American trials and approval process for AZ are clowns, and, if there weren't an ongoing pandemic related to the vaccine, their application should be rejected on that basis alone.
In the US, everything has been delayed by their incompetence so we've been sitting on millions of doses of the AZ vaccine waiting for them to complete their trials and to apply for emergency use authorization. If they had completed their trials and application competently, those doses could've been used by now.
To be fair, they can’t hurry the finish of a trial. Once the FDA asked them for more data they were stuck waiting for a certain number of events before they could analyse the data.
I’ve heard some people suggest that Oxford was the problem. They did all the early work in their first phase 3’s which turned out to be a shambles (not enough elderly, inconsistent dose, inconsistent dose interval) but AZ were involved by the time these US studies were set up, which have been much better designed and run.
Where AZ have shat the bed is with their communications. Press releases full of misleading claims, poorly explained and communicated supply issues etc
Anyway, I’m still convinced it’s a good vaccine. With solid evidence that it’s doing what it’s supposed to do in real life clinical practice. But yeah, hard not to wonder how this all worked out in a parallel universe where Hancock didn’t block the Merck partnership. Merck have loads of experience developing vaccines. AZ have none and it shows.
It was an exaggeration. At the very least it needs a caveat. There wasn’t enough numbers to make that claim.
Meanwhile 6% of Canadians have been vaccinated.
Our little tinpot dictator twat in Ottawa doesn't want to let go of his new power.
I didn't mean that they should rush the trial. It was delayed for almost 7 weeks because they dragged their feet providing evidence that two patients didn't suffer neurological side effects from the vaccine. Maybe there's some good justification for that, but it seems like administratively they bungled it.
https://www.nytimes.com/2021/03/11/us/politics/coronavirus-astrazeneca-united-states.html
Based off available data from trials it's 100% effective against hospitalisations/severe disease.
I think the combination of Oxford having no experience of running trials and AZ having no experience with vaccines is the root of basically all the problems.
It’s not powered to show that. None of those studies are. The 100% efficacy isn’t statistically significant. So we can’t rule out the possibility that it’s pure chance that the (small number of) hospitalised cases were all in the placebo arm.
Obviously the trends are encouraging and we might reach statistical significance eventually, by the time the studies are closed out. And it certainly doesn’t mean that they definitely aren’t 100% effective. They may well be. But, as it stands, those 100% efficacy claims need to be taken with a pinch of salt.
Sounds about right.
Joint football team? Nah
Huh? What statistical significance? 100% effective against hospitalization and death is a fact. That's not a comparison. In the people who got the vaccine, 0 hospitalizations or deaths happened. That's a fact. That's not a comparison that requires statistical significance to be valid.
Now you could argue the generalizability to real world and that needs to be determined with regards to AZN (correct me if I'm wrong) but real world experience with Pfizer in Israel has been awesome.
Every comparison requires statistical significance. Otherwise you can’t rule out that the findings are down to chance. Toss a coin three times and get three heads. It’s a fact that the coin has landed on heads 100% of the the throws so far. But you can’t claim it will have 100% chance of landing on heads every time you throw it. That’s why statistical significance matters.
These studies were all powered to demonstrate efficacy in terms of preventing covid. As soon as they had enough cases to reach statistical significance for that endpoint they were analysed and submitted to the regulators. But they didn’t have a high enough number of severe cases to make statistically significant claims about hospitalisations/deaths etc as the numbers were too low.
As I said, the trends are all in the right directions so it’s all encouraging stuff. Plus the real life evidence in Israel (and in the UK) look great. I just take issue with claiming 100% efficacy in an endpoint that didn’t reach statistical significance.
In case it wasn't posted. This is brilliant information for laymen like me 
Got mine yesterday evening. Didn't feel anything overnight or this morning so felt like a real man! Now I'm shivering cold for no reason, my muscles are aching, the injection site arm has become annoyingly sore and my head is feeling heavy with some pain too. Popped a paracetamol like a good little mummy's boy.
Paracetamol lasted 4 hours then back to shivering and heavy head with body aches. Took another paracetamol. This time symptoms settled but still got heavy eyes and fatigue. Hopefully won't need another paracetamol and sleep will fix the rest.
In case it wasn't posted. This is brilliant information for laymen like me
Watched that the other day and it was very well explained.
So I got mine on Monday as planned, the whole system at Torquay's English Riviera Centre was amazingly well run with so many volunteers who seemed genuinely happy to be working.
I felt fine Monday and woke up yesterday feeling just a bit groggy. Felt fine most of the day although I rested and did as little as possible. My arm became quite sore by mid afternoon, a very dull throb like someone had been repeatedly punching it for an hour, but other than that I just felt tired.
I felt fine Monday and woke up yesterday feeling just a bit groggy. Felt fine most of the day although I rested and did as little as possible. My arm became quite sore by mid afternoon, a very dull throb like someone had been repeatedly punching it for an hour, but other than that I just felt tired.
Just to be clear though, a test for statistical significance alone does not rule out anything by chance. A statistically significant result gives evidence of an effect. One may use the significance test to decide whether a data set merits further investigation.
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Had the Astrazeneca jab on Sunday, was fine Sunday night Monday morning then extreme fatigue set in. Had a bad night with shivers and a banging headache. Those symptoms went away Tuesday except for the fatigue. Just up after 10 solid hours sleep and feel great. Have had no arm pain at all, nothing except a wee bit of itching Sunday night. I did have the virus last year so was expecting the reaction tbh.
You need to take 2 paracetamol tablets as an adult, if they're 500mg ones. You can take up to eight in any 24-hour period.
Crazy, got the text this morning and booked for 9:30 this morning, wild 
My grasp of stats is pretty limited and restricted to the medical context only where a p value of < 0.05 is deemed statistically significant (95% CI excludes no effect) I’m sure there’s a lot more to it than this though!
Jesus that was the most incredible experience, got a text at 07:30 inviting me to come in, booked an appointment for 09:30, arrived at 09:15 and was jabbed by 09:17
Nice!
It's great isn't it? Congrats.
Congratulations mate, that is amazing.
It really is, all these volunteers making this happen so fast need a treat come the end of this because they’re doing an incredible job
I saw your posts about your gf the other day, has she seen the dr about her Asthma recently? Not to stick my nose into your business but if mine was acting up every time I went for a walk I’d probably wanna have a medication review, might give them a kick if it’s bad enough to push her for a vaccine too who knows
My gf is a nurse working at one of the vaccination hubs and has said that there was only 1 spare vaccine from any of the shifts that she's worked. And it was given as a second dose to one of the nurses.
The vaccines are in like blister packs of 9 and appointments are being rebooked if it would mean that a pack has to be opened and all the vaccines wouldn't be used.
It's all exceptionally well run
The vaccines are in like blister packs of 9 and appointments are being rebooked if it would mean that a pack has to be opened and all the vaccines wouldn't be used.
It's all exceptionally well run
Not sticking your nose in at all!
She requested two new inhalers from them the other day so surely they must know. I've asked her to call them but she doesn't want to block the line when it specifically says on the message that people should not call to ask when they'll get their vaccine.