SARS CoV-2 coronavirus / Covid-19 (No tin foil hat silliness please)

So if I read between the lines correctly:

Astrazeneca/Jannsen are useless against Omicron.
Pfizer and Moderna are ok, but you need to have had it recently. What's the 'peak protection period' ? After 8 weeks or so?
Past infection is ok too, but depending on how old/what variant it was, and how severe it was?
AZ and J&J don't look useless against serious disease. They do look useless against infection, unless you get a mRNA booster in which case the combination looks really good against infection or disease.

Pfizer/Moderna are weaker than were against infection but still having an impact for months after dose 2, but they look ok against Omicron infection once boosted.

Past infection is less predictable, it may protect against infection for a few months in some. It may protect against severe infection for longer.
 
AZ and J&J don't look useless against serious disease. They do look useless against infection, unless you get a mRNA booster in which case the combination looks really good against infection or disease.

Pfizer/Moderna are weaker than were against infection but still having an impact for months after dose 2, but they look ok against Omicron infection once boosted.

Past infection is less predictable, it may protect against infection for a few months in some. It may protect against severe infection for longer.

Perhaps the Canadians are just being cautious then as they are offering immediate boosters to any who had those vaccines. Is there any reliable data yet wrt combining vaccine types vs single vector vaccining? Is a cocktail likely to be the future best option?

How is Pfizer/Moderna efficacy against severe illeness without a booster? Is it as good/better than the above, or worse?

Are we likely to be in a situation now where it's likely to combine with another coronavirus to become worse?
 
Meant to get the train up to Scotland this week for Xmas. Just tested positive on lateral flow test. :( Will see what the PCR test says this week.
 
Its going to be a huge logstical undertaking to get the booster at the levels Boris wants.

GPs and secondary care will have to cancel a lot of routine work or appointments. Army will help, they've told us they're ditching the fifteen minute post-jab observation period that was a bit of a bottle neck in keeping lines going but will be massively challenging. With staff absences during christmas period, I just don't see how one million per day will be hit but let's see.
 
Perhaps the Canadians are just being cautious then as they are offering immediate boosters to any who had those vaccines. Is there any reliable data yet wrt combining vaccine types vs single vector vaccining? Is a cocktail likely to be the future best option?

How is Pfizer/Moderna efficacy against severe illeness without a booster? Is it as good/better than the above, or worse?

Are we likely to be in a situation now where it's likely to combine with another coronavirus to become worse?
We don't know enough to give real world Omicron estimates for severe disease following vaccines - it just hasn't been around for long enough for us to know. Indications are good though - there haven't been many severe cases leading to death so far and there hasn't been a massive rise in hospitalisations. It's hard to analyse right now because most cases that are more than two weeks old are in 20-40 year olds where case severity is usually low anyway. Plus most people affected in that age group in SA have prior infections. We'll find out a lot more in the next couple of weeks.

Lab analysis suggests that a AZ + Pfizer combination doesn't just give you a great quantity of circulating antibodies, it gives you a really good set of T and B cells. It might be that it's better to mix and match but we won't know until we get real world results.
 
Theres a little difference to an annual jab to getting one every 3 months.

The annual flu jab is co-ordinated with flu season though (winter), we're being asked to take a booster earlier both because it's winter and mainly because there's a new variant around. Pandemics are rare and we're going to have to do some unusual things to cope with it for a couple of years.

Eventually it will become either an annual jab or will just fade as the virus mutates itself into something less worrying.
 
Its going to be a huge logstical undertaking to get the booster at the levels Boris wants.

GPs and secondary care will have to cancel a lot of routine work or appointments. Army will help, they've told us they're ditching the fifteen minute post-jab observation period that was a bit of a bottle neck in keeping lines going but will be massively challenging. With staff absences during christmas period, I just don't see how one million per day will be hit but let's see.
It's almost like he's trying to distract people from something with a ludicrous plan...
 
We don't know enough to give real world Omicron estimates for severe disease following vaccines - it just hasn't been around for long enough for us to know. Indications are good though - there haven't been many severe cases leading to death so far and there hasn't been a massive rise in hospitalisations. It's hard to analyse right now because most cases that are more than two weeks old are in 20-40 year olds where case severity is usually low anyway. Plus most people affected in that age group in SA have prior infections. We'll find out a lot more in the next couple of weeks.

Lab analysis suggests that a AZ + Pfizer combination doesn't just give you a great quantity of circulating antibodies, it gives you a really good set of T and B cells. It might be that it's better to mix and match but we won't know until we get real world results.

What are your thoughts on those headlines we’ve seen this past week about hospitalisations doubling in South Africa? I’m assuming they’re clickbaity to an extent and there’s some big caveat.

Actually, were the source of those reports the same studies we saw that suggested these people were in hospital for other reasons and just happened to test positive for Covid during routine tests?
 
What are your thoughts on those headlines we’ve seen this past week about hospitalisations doubling in South Africa? I’m assuming they’re clickbaity to an extent and there’s some big caveat.

Actually, were the source of those reports the same studies we saw that suggested these people were in hospital for other reasons and just happened to test positive for Covid during routine tests?

If you read into you will find alot of these hospital cases are people in for other things that happen to find they are omicron positive when in the hospital.

9HfK3zK.jpg
 
What are your thoughts on those headlines we’ve seen this past week about hospitalisations doubling in South Africa? I’m assuming they’re clickbaity to an extent and there’s some big caveat.

Actually, were the source of those reports the same studies we saw that suggested these people were in hospital for other reasons and just happened to test positive for Covid during routine tests?
A lot of them were positive tests on arrival at hospital for a different reason (it decides which ward you put people on and what PPE the staff wear).

Some were positive tests on people with serious pre-existing conditions (like being on oxygen at home) or on babies - who were taken in on a precautionary basis. The fact they had enough capacity to do anything on a precautionary basis is actually good news!

Then there's the actual new covid cases. They had next to no covid cases in SA in the weeks before Omicron hit, so any covid case represents a rise.

The good news is that the average hospital stay is shorter and that deaths are rarer.

The proviso is that we don't have much news yet on the over 60s or on people who are immune naive (no prior infection and no vaccine). Fingers crossed eh
 
If you read into you will find alot of these hospital cases are people in for other things that happen to find they are omicron positive when in the hospital.

9HfK3zK.jpg
A lot of them were positive tests on arrival at hospital for a different reason (it decides which ward you put people on and what PPE the staff wear).

Some were positive tests on people with serious pre-existing conditions (like being on oxygen at home) or on babies - who were taken in on a precautionary basis. The fact they had enough capacity to do anything on a precautionary basis is actually good news!

Then there's the actual new covid cases. They had next to no covid cases in SA in the weeks before Omicron hit, so any covid case represents a rise.

The good news is that the average hospital stay is shorter and that deaths are rarer.

The proviso is that we don't have much news yet on the over 60s or on people who are immune naive (no prior infection and no vaccine). Fingers crossed eh

Thanks!
 
My favourite bit was that having advised people to work from home if possible, he then suggested that work parties can go ahead as planned.
The work from home advice is to reduce transmission during the peak hours for public transport 7:30-9am and 5-6pm. That time when platforms are cramped and carriages are filled with people literally up each other.
 
I got my booster today. Mask wearing is being adhered to on trains. Not in supermarkets but if that changes I don't have a problem.
 
Anyone use Twitter spaces? There’s a guy on there who’s been running debates and it’s really enlightening for the general level of ignorance out there in the younger generation.

https://twitter.com/jacobbmc2?s=21

Damn. That was genuinely bewildering. It's baffling the sheer amount of disinformation that can be absorbed by people in order to simply validate an initial viewpoint, yet the most basic facts on the issue are totally new to them.

Listening to that just makes you realize that there is probably no chance of getting close to natural immunity on vaccines alone, here's hoping these new variants prove less severe.
 
Theres a little difference to an annual jab to getting one every 3 months.

No one is asking anyone to get one every 3 months. Currently you have to wait 6 months for a booster on average which is probably going to become 9-12 months soon.
 
I have a question.
I'm travelling to the UK on Wednesday (Booked when only double vax was required) and I need to have a negative LFD test in order to gain entry. Is it enough with a home test kit? Do I take the device with me to the airport? I have already booked a Day 2 PCR .
 
I have a question.
I'm travelling to the UK on Wednesday (Booked when only double vax was required) and I need to have a negative LFD test in order to gain entry. Is it enough with a home test kit? Do I take the device with me to the airport? I have already booked a Day 2 PCR .

No because in reality what you need is a fit to fly certificate.

You'll need to book a supervised test which then gives you a certificate, which can be verified to say that you took the test & are negative. I flew back from the US yesterday, and all of the verification was done using the verifly app prior to checking in - at the airport they only checked verifly was green rather than checking all the individual documents.
 
Its going to be a huge logstical undertaking to get the booster at the levels Boris wants.

GPs and secondary care will have to cancel a lot of routine work or appointments. Army will help, they've told us they're ditching the fifteen minute post-jab observation period that was a bit of a bottle neck in keeping lines going but will be massively challenging. With staff absences during christmas period, I just don't see how one million per day will be hit but let's see.
There’s nothing Tory voters love more than ”the Army being brought in to help”.
 
No because in reality what you need is a fit to fly certificate.

You'll need to book a supervised test which then gives you a certificate, which can be verified to say that you took the test & are negative. I flew back from the US yesterday, and all of the verification was done using the verifly app prior to checking in - at the airport they only checked verifly was green rather than checking all the individual documents.

Ah ffs. I though I could just do a home-test one.
 
No because in reality what you need is a fit to fly certificate.

You'll need to book a supervised test which then gives you a certificate, which can be verified to say that you took the test & are negative. I flew back from the US yesterday, and all of the verification was done using the verifly app prior to checking in - at the airport they only checked verifly was green rather than checking all the individual documents.
The tests needed before coming to the UK don't need to be supervised.