Crimea is the most protected Russian space with air defense, mostly with S400 (plus useless systems like pantsir and more). 2 systems were already destroyed by a nation that has a handful of semi modern cruise missiles, next to 0 air force, uses mediocre anti ship missiles like the Neptune to hit ground targets and even very old S200 missiles.
Now I know why Ukraine can do this and it's not because they are using 5th get aircraft or NSM or any real tech from the West in terms of stealth. It is because they use fairly standard decoys (small missiles that have the radar cross section of a plane or large cruise missile) and the S400 radar can not tell the difference, so it gets overwhelmed easily. The S400 is a pile of something not because of the performance of the interceptors, but because the radars and identification of targets is at most 1990s level.
F16 will do very well because Russian radars are extremely vulnerable to decoys and thus easily overwhelmed to the point where they themselves become the main target. Put this in to comparison with the 2 Patriot systems that are protecting Kiev and how impposible it is for the orcs to do major damage here, let alone to accually destroy these systems.