Tricky one without knowing a lot more information!
How many FTs? Money in the bank? How many -4 hits would you be willing to take before WC becomes a must?
How committed to keeping Saka and Palmer are you? Bit unusual to see both of them in a team, workable though with some good budget options in midfield so far. I'd be tempted to start there if not wildcarding, or rejig the make up of the team with only one of them moving forward if I did WC.
Jota, Amad, Yarmo is 17m. If you really want Jota out you can have ESR, Semenyo and Rogers for that. It gives you at least one better bench option, rotational options when it comes to picking the team depending on fixtures and 0.4 in tha bank.
Wouldn't have thought taking -4s was a good idea for subs, but none of those are strict subs, all poentially getting future gametime for you. Amad isn't awful, could look to keep him at a pinch and just move Jota and Yarmo for 2 of them if it saves a -4?
Whatever you do there needs to be a plan. No point taking a few -4s only to WC next week anyway.
Isak has been useless and now faces City. So tempting to say shift him too but that's another potential -4. Could always bench him and move him on next depending on what else you do.