Part of me commends ETH for trying VdB again as you want to give a player more than one chance to impress, but I think it was unwise to do so with Eriksen in the same midfield. Both looked way off the pace yesterday and basically left Casemiro on an island to shield the defense. Only one of the two should have started and then Fred should have taken the place of the other to provide the necessary energy. Couple that with Ronaldo offering nothing and playing Rashford off the right (where he's about as useless as one can be) and it's clear ETH got it wrong yesterday.
I stayed off the cafe post-match because I knew there would be some disgusting overreactions, but it's quite clear how vital it is to have at least two of Martial, Sancho, or Antony fit to add that technical quality into our attack. Without any of them able to start, we didn't really have a player to relieve the pressure, and added to the lack of legs in midfield we basically were overrun by Villa on the break.
All in all, we need to get fit in attack and figure out an ideal secondary midfield when the first choice isn't available. It's also quite clear how finished Ronaldo is (but that's already been mentioned), and it's also clear that we need to bring in another CB (please Ndicka). Neither Maguire nor Lindelof are good enough to step up in the absence of our top 2, and it would be smarter to have a third rotational CB that's young/athletic that can use those minutes to develop.