Actually The Wire and Sopranos didn't have that "American" in them (Leftovers do btw haha).
But what I mean by "American", I find it a bit hard to describe. It's like smoothing out all the difficult things and ruff edges with some quirky stuff and make everything not-so-serious, you know, sugarcoating stuff.
How could you get more American than The Sopranos or The Wire? I think you must be mixing up a narrative style with nationality or something like that.