With a midfield pairing of Ando/Cleverley we scored fourteen goals and conceded just two in five games which included City, Arsenal and Spurs as opponents; against just those three they scored ten and conceded just one. The pairing was a great success and with it we played the best football of our entire season, and yet you're still questioning their suitability to play together?
By my reckoning we've got two strong midfield partnerships in Carrick/Scholes and Ando/Cleverley, that's without even mentioning Giggs, Kagawa, Jones and Powell. If we're hit by extensive long-term injuries then that's just bad luck, it's something which really can't be helped; as I've said above, if SAF had concerns about Anderson, Cleverly or Carrick's fitness then he wouldn't be going into a season relying upon them. It's easy to point out injuries in hindsight, but if SAF has been given the okay from his medical team regarding the aforementioned players for the season ahead then he'll trust that judgement and just hope for better luck this time around.
Managers don't plan for multiple long-term injuries by buying direct replacements just in case a crisis arises, they cannot afford that luxury whilst keeping everybody happy, what they do instead is they simply bodge makeshift XI's in in such circumstances and hope for the best. IIRC only Manchester City managed to get through last season largely un-effected by injuries, and that was a case of old fashioned blind-luck rather than any impenetrable squad-depth that Mancini has masterminded; when they
did lose Yaya Toure the effect was noticeable. They've signed Rodwell as support, but has that made them really all that much stronger?
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Nasri Cleverley
Rodwell Powell
Barry Carrick
Silva Kagawa
De Jong Anderson
Toure Scholes
I honestly can't see much difference there in terms of depth and quality. Try picking the best six players from those twelve; I bet you no matter how often you attempt it you won't be able to justify selecting more than three of the City players.