The shopping-centric day is among Amazon's busiest all year.
The Make Amazon Pay group says: "Amazon takes too much and gives back too little."
It is backed by a coalition of labour groups, trade unions, grassroots campaigns and non-profit-making organisations in individual countries.
In the UK, that includes the:
GMB Union
Trades Union Congress
Momentum
War on Want
International Transport Workers' Federation
Labour Behind the Label
No UK Amazon warehouses are unionised, so legally they can't strike.
Many employees will be working on the day, but campaign groups which include Amazon workers will be staging protests at Amazon buildings in Coalville, Leicestershire, Coventry, Peterborough and at its London headquarters.
But strikes are being encouraged elsewhere.
In Germany, for example, the union Verdi called on employees at major shipping centres to strike, beginning on Wednesday night.
Worldwide, nearly 50 organisations have signed up to a list of "common demands", published by the Make Amazon Pay coalition, which include:
raising warehouse workers' pay and adding hazard pay and peak time increments
halting worker "surveillance" and strict productivity targets
extending sick leave and improving Covid-19 tracking and reporting
ending casual employment status and "union-busting" activities
paying taxes without using loopholes or tax havens
"This company is a pandemic profiteer can afford to do better," said Mick Rix, from the GMB Union. "It's time for Amazon sit down with their workers' union GMB and make Amazon a great, safe place to work. "
Amazon reported a tripling of profits earlier this year, attributed to its success during the Covid-19 pandemic.