VP changes and whatnot
http://wiki.answers.com/Q/Has_a_US_President_changed_vice_Presidents_between_terms
Appears to only have happened due to death or resignation. That said, I highly doubt Biden has a shot at POTUS after Obama. He'll be too old and I just do not think he has that electibility about him. But anyone other than Hillary please.
Electoral colleges and national vote winners
http://www.archives.gov/federal-register/electoral-college/faq.html#ecpopulardiffer
The link has a segment that mentions over 700 proposals have been submitted in 200 years to change this process. I doubt we'll see a change in our lifetime taking that into account. Nor am I positive the electoral college should be changed. It gives the "small" states a voice.
--How is it possible for the electoral vote to produce a different result than the nation-wide popular vote?
It is important to remember that the President is not chosen by a nation-wide popular vote. The Electoral College vote totals determine the winner, not the statistical plurality or majority a candidate may have in the nation-wide popular vote totals. Electoral votes are awarded on the basis of the popular vote in each state.
Note that 48 out of the 50 States award Electoral votes on a winner-takes-all basis (as does the District of Columbia). For example, all 55 of California’s Electoral votes go to the winner of the state election, even if the margin of victory is only 50.1 percent to 49.9 percent.
In a multi-candidate race where candidates have strong regional appeal, as in 1824, it is quite possible that a candidate who collects the most votes on a nation-wide basis will not win the electoral vote. In a two-candidate race, that is less likely to occur. But, it did occur in the Hayes/Tilden election of 1876 and the Harrison/Cleveland election of 1888 due to the statistical disparity between vote totals in individual state elections and the national vote totals. This also occurred in the 2000 presidential election, where George W. Bush received fewer popular votes than Albert Gore Jr., but received a majority of electoral votes. --
My two cents: Perhaps changing the vote to account for the overall percentage of each state would make a difference, i.e. a close state vote of say 52-48 would see roughtly 52% of state electoral votes to one candidate and 48% to the other candidate. This would ulimately mirror the national vote.