The vaccines | vaxxed boosted unvaxxed? New poll

How's your immunity looking? Had covid - vote twice - vax status and then again for infection status

  • Vaxxed but no booster

  • Boostered

  • Still waiting in queue for first vaccine dose

  • Won't get vaxxed (unless I have to for travel/work etc)

  • Past infection with covid + I've been vaccinated

  • Past infection with covid - I've not been vaccinated


Results are only viewable after voting.
Yes. I’ve heard that suggested. If you’re absolutely flattened by the vaccine that might mean you would have been flattened by covid too. A big factor in the people made most sick by covid is an exaggerated immune response. So an exaggerated immune response to the viral spike protein in the vaccine could be a red flag.

I can only imagine then what full covid must be like for those who get it bad, because i was out bad enough for one day with the second dose of moderna. I mean i was still able to get up and do things, but i had a fever and was seeing double as well. The next day it was still lingering but had gotten much better.
 
Finally started getting more supplies here end of July so got my first shot August 1. Was Astrazenca so hate that I have to wait until September 26 the earliest to get the second dose.
 
I just wonder if you get it bad from the vaccines, does that mean you would get covid really bad too? I got my second dose of moderna on sunday and had a fever on monday. But it cleared up by tuesday. But my mothers friend was saying her daughter was knocked out for six days. My aunt as well was out for a week with it. The vaccine that is.
I had Covid in December and the first jab was around as bad but my symptoms weren't wild either way. Only really had pain at the injection site for 4 days, a few headaches and some slight soreness intermittently. The latter two have me wondering if I caught Covid though. When I had Covid before it was the joint pain as above along with excessive coughing and chest pain.

Does anyone know if that should stop me from getting the second dose considering it's said one should wait about 3 months after Covid infection to get vaccinated? Think I'll still go through though as can't be bothered waiting longer than the 2 months.
 
In the NSW outbreak we have had over 6000 cases with all or the vast majority being Delta. So far 99% of infections have not been fully vaccinated (92% unvaccinated and 7% partially vaccinated). We have had one death of a man in his 90's who was fully vaccinated and zero admissions to ICU, much less ventilated.

Looks like AZ and Pfizer are doing a great job with Delta.

Do you think the vaccines will be looked back at as a marvelous achievement Wibble?
 
An interesting look at what the (real life) vaccine efficiency calculations are telling us about impact of vaccines on hospitalisations.

Broadly, he's taking the age by age take-up rates for the vaccine, the known case v hospitalisation percentage in each age group (if unvaccinated) and then telling us what impact the vaccine is likely to have on hospitalisations.

Portugal who've done a great job on take-up top the table, Ireland doing great as well. The US and some other countries, despite having lots of vaccine available, haven't had the same kind of take-up rates, even amongst their most vulnerable.



To get an idea of what take-up rates mean in practice, take a look at Florida. They currently have around 15,000 people hospitalised - with a population a third of the UK (currently around 6,000 hospitalised). Florida's hospitalisation numbers are now higher than they've been at any time during the pandemic.

Florida's stats are not the vaccine's fault. They're what happens if you don't vaccinate enough, despite having the ability to do so.


De Santis is a dangerous fecking moron
 
Do you think the vaccines will be looked back at as a marvelous achievement Wibble?

They should be but with the amount of feckwittery around at the moment who knows? People forget we could be sitting here with no vaccine and deaths skyrocketing and economies actually collapsing. We would be fecked basically. Developing such effective and safe vaccines at such a pace is a stunning achievement.
 
Is there any validity in the thinking that some circulation of the virus among the population keeps antibody levels quite high in the vaccinated groups? Especially those, who's antibody levels are already high enough to avoid getting infected

If your antibody levels are high enough (or perhaps the right way of looking at it is if your IgA levels in nasal mucosa work well enough to prevent you getting infected) then you wont develop new antibody levels or boost your antibody levels, meaning the virus circulating in the population wont keep the antibody levels high. Does that make sense?

They should be but with the amount of feckwittery around at the moment who knows? People forget we could be sitting here with no vaccine and deaths skyrocketing and economies actually collapsing. We would be fecked basically. Developing such effective and safe vaccines at such a pace is a stunning achievement.

History will record it as such. And mRNA will revolutionize preventive medicine IMO.
 
Thanks. Enjoyed that. Seems Harris has fallen out with a number of his former friends in the last 9 months over his pro-vaccine stance (the likes of Maajid Nawaz and Bret Weinstein have completely disappeared down the looney anti-vaxx rabbit hole).

What's Bret Weinstein's vax position?
 
If your antibody levels are high enough (or perhaps the right way of looking at it is if your IgA levels in nasal mucosa work well enough to prevent you getting infected) then you wont develop new antibody levels or boost your antibody levels, meaning the virus circulating in the population wont keep the antibody levels high. Does that make sense?

Where does the IgA in mucosa cells come from? Antibodies or memory cells or anther part of the immune system? And presumably there is adaption for specific antigens?

History will record it as such. And mRNA will revolutionize preventive medicine IMO.

I bloody well hope so. The number of Covidiots and FREE DUMB floating around at the moment makes me wonder.
 
8-12 weeks is the recommended timeline for getting the second dose. So 2-3 months basically.

For AZ? If so it was originally trailed with 8 to 12 week gaps between shots. Most places pushed towards 12 weeks to get as many people their first shot as soon as possible but some places like Australia, where AZ supply is fine, have now moved from 12 weeks to 4 weeks minimum to try to limit a serious outbreak of SARS-CoV-2 Delta.
 
If given the choice, why wouldn't people do JNJ's? One and done...

One shot an advantage but effectiveness isn't as good as the mRNA vaccines although still great against death/hospitalisation. I also think there are concerns that clotting might also be an issue as it is for AZ.
 
Where does the IgA in mucosa cells come from? Antibodies or memory cells or anther part of the immune system? And presumably there is adaption for specific antigens?



I bloody well hope so. The number of Covidiots and FREE DUMB floating around at the moment makes me wonder.
IgA themselves are antibodies, produced by B lymphocytes. Their role is in mucosal areas. Yes different antigens elicit different antibodies.
 
One shot an advantage but effectiveness isn't as good as the mRNA vaccines although still great against death/hospitalisation. I also think there are concerns that clotting might also be an issue as it is for AZ.

How would you rank Pfizer, Moderna and Jnj in terms of effectiveness?
 
How would you rank Pfizer, Moderna and Jnj in terms of effectiveness?

Hard to be certain as the data I see for each isn't always comparable (and of course I don't see or know of all of the data).

For Delta Pfizer has 96% effectiveness against hospitalisation, 83% against symptomatic and 79% against asymptomatic infection , which is very good indeed and a Delta tweak is on its way.

Moderna haven't given figures for asymptomatic infection or any Delta specific data but given the similarities to Pfizer in the original trials to isn't impossible that they are broadly the same. Delta tweak also on its way.

AZ has 92% effectiveness against hospitalisation, 61% against symptomatic and 60% against asymptomatic infection against Delta. Very rare clotting a risk particularly for younger age groups.

J&J is is 71% effective against severe covid from delta (I'm assuming severe = requires hospitalisation) but other data is scare. Very rare clotting a risk particularly for younger age groups.

On that basis I'd rank them.
  1. Pfizer (as better data)
  2. Modena (maybe the same but data lacking)
  3. AZ
  4. JJ
But there are all very good so in general I'd say the best vaccine is the one in your arm - don't delay. I got AZ the moment I could and if I'd waited for Pfizer I'd still be waiting most likely.

If you live in NZ and are under 50/60 I might risk holding off for an mRNA vaccine but elsewhere I wouldn't delay getting vaccinated waiting for a "better" vaccine as the risk of getting covid where it is widespread and the risk of a very severe outcome is greater than the risk of a clot in all age groups currently eligible for vaccination.
 
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Hard to be certain as the data I see for each isn't always comparable (and of course I don't see or know of all of the data).

For Delta Pfizer has 96% effectiveness against hospitalisation, 83% against symptomatic and 79% against asymptomatic infection , which is very good indeed and a Delta tweak is on its way.

Moderna haven't given figures for asymptomatic infection or any Delta specific data but given the similarities to Pfizer in the original trials to isn't impossible that they are broadly the same. Delta tweak also on its way.

AZ has 92% effectiveness against hospitalisation, 61% against symptomatic and 60% against asymptomatic infection against Delta. Very rare clotting a risk particularly for younger age groups.

J&J is is 71% effective against severe covid from delta (I'm assuming severe = requires hospitalisation) but other data is scare. Very rare clotting a risk particularly for younger age groups.

On that basis I'd rank them.
  1. Pfizer (as better data)
  2. Modena (maybe the same but data lacking)
  3. AZ
  4. JJ
But there are all very good so in general I'd say the best vaccine is the one in your arm - don't delay. I got AZ the moment I could and if I'd waited for Pfizer I'd still be waiting most likely.

If you live in NZ and are under 50/60 I might risk holding off for an mRNA vaccine but elsewhere I wouldn't delay getting vaccinated waiting for a "better" vaccine as the risk of getting covid with a very severe outcome is greater than the risk of a clot in all age groups currently eligible for vaccination.

Oh thanks mate - I got the JNJ back in April, the first day they were offered up to the general population here in NYC (i.e. not the elderly or the immunocompromised). Part of the reason I got J&J was the old school viral vector technology which was so successful against Ebola and of course the convenience of one shot vs two.

I was just curious about effectiveness because recently the US Food and Drug Administration (FDA) authorized Pfizer and Moderna COVID-19 vaccine booster shots for certain people who are immunocompromised and these individuals who can receive the booster, will be administered the same Pfizer or Moderna shot they received previously. Those who received the Johnson & Johnson vaccine, will receive a Pfizer shot.
 
Its 12 weeks here in India.. was 4 weeks initially (rejected the upto 12 weeks suggestion and stuck to 4)... shortages made it 6-8 weeks.. further shortages made it 12 weeks..
Now there seems to be enough.. Hasnt changed in the last 2-3 months..
 
Oh thanks mate - I got the JNJ back in April, the first day they were offered up to the general population here in NYC (i.e. not the elderly or the immunocompromised). Part of the reason I got J&J was the old school viral vector technology which was so successful against Ebola and of course the convenience of one shot vs two.

I was just curious about effectiveness because recently the US Food and Drug Administration (FDA) authorized Pfizer and Moderna COVID-19 vaccine booster shots for certain people who are immunocompromised and these individuals who can receive the booster, will be administered the same Pfizer or Moderna shot they received previously. Those who received the Johnson & Johnson vaccine, will receive a Pfizer shot.

My BIL in Texas got J&J but my SIL got Pfizer - luck of the draw. Unless you live somewhere covid free the first vaccine available is the best IMO. I'd guess many of us with get a third shot of Pfizer or Modena no matter what the first vaccine was once they tweak them for Delta as there isn't much data suggesting that we need an immediate booster for declining immunity in general, as far as I can tell.
 
Not sure if it's the impact of a long weekend with poor sleep, going to the gym yesterday or having my second jab yesterday (or a combination of these things) but I'm feeling pretty fatigued today. Had plenty of sleep but I've had low energy and pretty heavy eyes since waking up today. Arm is still sore but it was probably a little worse when I went to bed last night.
 
Not sure if it's the impact of a long weekend with poor sleep, going to the gym yesterday or having my second jab yesterday (or a combination of these things) but I'm feeling pretty fatigued today. Had plenty of sleep but I've had low energy and pretty heavy eyes since waking up today. Arm is still sore but it was probably a little worse when I went to bed last night.

Which vaccine?
 
Has anyone travelled to France recently (in particular by Ferry)? Were they strict with checking your vaccination status proof?
 
Has anyone travelled to France recently (in particular by Ferry)? Were they strict with checking your vaccination status proof?

Strict as in do they check you have one, or strict as in do they check if its a fake or not? The former yes, the latter no. Though you would be running one massive risk if you had a fake.
 
Must read thread as the Israel data has been misunderstood regarding vaccine efficacy.

 
Strict as in do they check you have one, or strict as in do they check if its a fake or not? The former yes, the latter no. Though you would be running one massive risk if you had a fake.

Hopefully that risk is a massive fine and prison.
 


Not surprising. I do wonder if hey are going to tweak the mRNA sequence or continue on. Although this does raise the question, and apologies if this has been discussed, of whether future COVID vaccines that contain a slight sequence change will be required to go through a complete submission process.
 
Must read thread as the Israel data has been misunderstood regarding vaccine efficacy.


Yep, I was reading those numbers earlier. It's remarkable just how different they look once you break them down into the age bands.

I'm still not sure what is really being observed on the vaccine efficacy waning stuff either. Preparing to use boosters on some risk groups sounds reasonable, but I think there may be confiding factors we're missing in the Israeli data that's being cited.
 
The title mades me think that I needed to drink more coffee. :nervous:
 
I had a fever and was tired after my second dose of moderna. Two days later i was better.
Sounds about right. I had mine on Sunday and was wiped Monday. Here we are on Wednesday and I'm still pretty tired.
No fever for me fortunately but just feeling pretty drained. Didn't experience any of this with the first dose.

My hope is that I'm perfectly fine for the weekend at least.