Wouldn't want to be the guy who messed up
The vaccines | vaxxed boosted unvaxxed? New poll
- Thread starter Badunk
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Wouldn't want to be the guy who messed up
If you’v got the right QA procedures in place it shouldn’t be possible for human error to cause such a massive cock-up. FFS.
J&J need to sort their shit out here. The one dose approach and relatively high storage temperatures is an absolute lifesaver for third world countries.
I'd immunise my kids in a flash after such studies as it will contribute to efforts to get to the HIT.
The German doctor who first raised the clotting issue has said there is only a very small risk, that is a number of orders of magnitude less than getting covid, so we should continue vaccinating.
My only question would be "Are the risks associated with the Astrazeneca vaccine greater than the risks from contracting Covid?"
If the answer is a negative then carry on and get vaccinated.
Is there any correlation with those who have suffered the reaction being the same as those who are at most risk of contracting Covid i.e immuno suppressed, respiratory illnesses etc?
If the answer is a negative then carry on and get vaccinated.
Is there any correlation with those who have suffered the reaction being the same as those who are at most risk of contracting Covid i.e immuno suppressed, respiratory illnesses etc?
Good news about AZ/Oxford and the UK variant
https://www.news-medical.net/news/2...ffective-against-B117-SARS-CoV-2-variant.aspx
https://www.news-medical.net/news/2...ffective-against-B117-SARS-CoV-2-variant.aspx
On the kids issue, and the does vaccination reduce infection as well as disease question, a bit of (good) news from Israel.
The preprint (beyond the summary and the graphs) is definitely for the statistically enthusiastic, the rest of us should read Hilda's tweets on it instead
The preprint (beyond the summary and the graphs) is definitely for the statistically enthusiastic, the rest of us should read Hilda's tweets on it instead
On the kids issue, and the does vaccination reduce infection as well as disease question, a bit of (good) news from Israel.
The preprint (beyond the summary and the graphs) is definitely for the statistically enthusiastic, the rest of us should read Hilda's tweets on it instead
Isn't that exactly what you might expect? The move to vaccinate kids will presumably only gain urgency if we can't get to HIT without vaccinating 12-18 year olds or even younger.
Not that they know about yet. The problems seem to be with young, healthy females.
The question for that group is whether the risk of the vaccine is higher than the risk of catching the virus, and then ending up in hospital with it, also considering there are now other vaccines available. Regulators are still trying to understand that.
The Oxford/AstraZeneca group have updated their UK trials data. They now have more cases (because the trial period was that much longer), and they've been able to split out data for those with the UK variant versus those with the original one.
The good news is that the efficacy looks good - probably benefiting from the longer time period from vaccination to infection. The quoted efficacy (all symptom severity) now looks like 70% against the UK variant, 81% against the original strain. Which is not a surprise since we're also seeing high levels of protection in the analysis coming from the UK rollout.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00628-0/fulltext
The good news is that the efficacy looks good - probably benefiting from the longer time period from vaccination to infection. The quoted efficacy (all symptom severity) now looks like 70% against the UK variant, 81% against the original strain. Which is not a surprise since we're also seeing high levels of protection in the analysis coming from the UK rollout.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00628-0/fulltext
Do we have a feel from previous vaccines, how long we might expect the Ox/AZ and J&J vaxs to take to reach maximum protection? I've seen a few people suggest that it builds up over a longer time (so, for example, the South African trial might not be as bad as it appeared) but don't really know how much to take from that.
So far I've only been a bit sore on my arm and jaded. Nothing I couldn't be anyway from my normal life.
Oh, and body akes like hell, but that's been around for years.
Oh, and body akes like hell, but that's been around for years.
I've been told 2 weeks until you are considered protected.
But that information might be outdated.
Seems to be a bit of radio silence on the clotting issue from U.K.
That’s the first time (I think?) we’ve seen any suggestion of reduced vaccine efficacy against UK variant. Although confidence intervals are wide and efficacy decent overall.
Not really. The MHRA initial review has identified 5 cases of CSVT that may be related (by timing) to the vaccine in men under the age of 60. Which doesn't seem to fit the pattern observed in Germany/Norway where the main clusters have been seen in women.
They're now asking all haematology units to review all CSVT and newly diagnosed thrombocytopenia cases in the period to make sure that vaccine status is checked and they get added to the database even if the doctors treating them identified (or thought they had identified) other causes.
Meanwhile the national guidance to hospital doctors has been updated to:
https://b-s-h.org.uk/about-us/news/covid-19-updates/
Which gives some methodology cautions (like how to do the PF4 test) as well as treatment advice. They're operating a daily specialist panel session to analyse any new data and to give advice to hospital doctors who have patients to diagnose or treat.
The raw advice to people receiving the vaccine now has sustained headache, blurred vision, multiple unexplained bruises/pinprick bruises as warnings to "seek medical advice".
Pfizer has announced it's vaccine remains 91% effective after 6 months. Excellent news for the concerns about protection dropping off after a few months.
Fantastic. Getting closer and closer to an annual booster being all that’s required.
Still be a huge job every year
Not all that much work in addition to what we already do with annual flu jab (1 million people got flu vaccine in Ireland last year)
Yeah but nearly 5m in a short space of time no?
My wife's arm is still dead 4 weeks after the AZ jab.
A hassle but doable. Combination of pharmacists and at your place of work. Obviously the hope would be efficacy lasting > 12 months.
Do we think an annual booster might be necessary for all adults, or just those identified as falling within the various higher risk categories (à la flu)?
What are doing in normal life that makes your arm sore. Oh wait a moment...
Not that the drop off is necessarily linear, but 94% to 91% in 6 months gives hope a booster might not be needed so frequently. Or at least it can be staggered.
Pfizer press release on efficacy (now coming in at around 91% using data from their clinical trial group) and with a first look at the SA strain where a small (800 person) trial has seen 100% efficacy. Don't get too carried away with that 100% just yet though - it actually relates to 0 cases in the vaccinated group versus 6 cases of the variant in the unvaccinated - good news though.
https://www.businesswire.com/news/home/20210401005365/en/
https://www.businesswire.com/news/home/20210401005365/en/
Sleeping on it.
BBC News - Covid: Europe's vaccine rollout 'unacceptably slow' - WHO
https://www.bbc.co.uk/news/world-europe-56600660
I really hope things can start picking up in Europe in coming months. With the positive news about the vaccines if we can get acceptable numbers of people protected we can start to slowly see some normality again.
https://www.bbc.co.uk/news/world-europe-56600660
I really hope things can start picking up in Europe in coming months. With the positive news about the vaccines if we can get acceptable numbers of people protected we can start to slowly see some normality again.
I don't think anybody listens much to the WHO anymore. They're quickly dismissed by pretty much everybody in Italy after their handling of the pandemic.
There are few surprises in Europe despite certain news stories. We were about 15% down on expected deliveries during Q1. During Q2 we are expecting 400m doses to arrive, a 4x increase and almost enough for everybody on the continent. It's then up to individual countries to get them into arms.
Ahh the old stranger.....
Here I was thinking the point of sleeping on it being that It didn't feel as usual.
In ireland we were meant to get 1m, it’s already down to just over 800k. This company is a disgrace
Good news re Pfizer vaccine and SA variant. Small numbers (so statistical significance dubious) but still...
We getting something like 10m-20m doses of Pfizer in Q3, so we’ll know for sure soon enough.
MHRA weekly update for adverse reactions reports is now up on:
https://www.gov.uk/government/publi...irus-vaccine-summary-of-yellow-card-reporting
The yellow card events themselves are logged n:
https://assets.publishing.service.g...VID-19_AstraZeneca_Vaccine_Analysis_Print.pdf
but that contains raw numbers and a lot of duplicates (multiple symptoms/classifications from one patient) rather than how those symptoms fell across different age groups etc and which ones already have another non-vaccine diagnosis. Keep in mind the simple fact that with 18m people, many of them elderly or with underlying conditions - some people will get sick/die in the month after vaccination.
Headline news is that the study into thrombocytopenia is ongoing. They're now looking at 44 cases (across 18 million doses) with 1 associated death of thrombocytopenia and 24 cases CVST with 4 associated deaths. The data isn't split out unambiguously in the summary report but it reads like those 24 CSVT's may have included 22 cases with thrombocytopenia.
Again, the detailed analysis will be what matters because cases of CSVT and thrombocytopenia do happen to normal (and otherwise healthy looking) people every week. The raw numbers in the UK at the moment (5 deaths that may be related to the 18 million vaccine doses given) haven't changed the MHRA advice which is that for almost everyone it's safer to take the vaccine if offered than to delay. Meanwhile the clinicians and the regulators will keep looking for risk factors and explanations, and improving the treatment plan for people it might affect.
https://www.gov.uk/government/publi...irus-vaccine-summary-of-yellow-card-reporting
The yellow card events themselves are logged n:
https://assets.publishing.service.g...VID-19_AstraZeneca_Vaccine_Analysis_Print.pdf
but that contains raw numbers and a lot of duplicates (multiple symptoms/classifications from one patient) rather than how those symptoms fell across different age groups etc and which ones already have another non-vaccine diagnosis. Keep in mind the simple fact that with 18m people, many of them elderly or with underlying conditions - some people will get sick/die in the month after vaccination.
Headline news is that the study into thrombocytopenia is ongoing. They're now looking at 44 cases (across 18 million doses) with 1 associated death of thrombocytopenia and 24 cases CVST with 4 associated deaths. The data isn't split out unambiguously in the summary report but it reads like those 24 CSVT's may have included 22 cases with thrombocytopenia.
Again, the detailed analysis will be what matters because cases of CSVT and thrombocytopenia do happen to normal (and otherwise healthy looking) people every week. The raw numbers in the UK at the moment (5 deaths that may be related to the 18 million vaccine doses given) haven't changed the MHRA advice which is that for almost everyone it's safer to take the vaccine if offered than to delay. Meanwhile the clinicians and the regulators will keep looking for risk factors and explanations, and improving the treatment plan for people it might affect.
I had my first jab yesterday. It's the Sinovac one, which along with AZ is the only ones available right now here in Indonesia, but better than nothing and beyond elated nonetheless. No side effects throbbing pain on injection site aside. Have you had yours, @Sky1981?
Not over 60s. But most of my elder relatives and parents have had them.
Can't complain this time. Our governent did the best considering everything else.
9 deaths doesn't mean the rest is fine though. If you look at it that way it's worrying.
It means the problem exists