Won't be too harsh on him given he's being played out of position, a position that accentuates his weaknesses.
Expecting Rashford to play centrally with tight coverage on him every time he's got the ball is pointless. He doesn't maneuver well in tight windows and spaces nor is he good playing with his back to goal, holding off guys. His inconsistent touch will always make sure he gives the ball away more often than not when he receives the ball while a guy is on him let alone multiple guys as he'd often find himself in that situation playing centrally.
Put him back on the left and take advantage of his ability to attack the space, especially in transition, that's his strength. I'm confident Rashford would have made a lot more of the opportunities Garnacho found himself in today while in transition with plenty of space to attack. It's really pointless watching Rashford give the ball away because his initial touch while being pressure from all sides is loose and playing centrally there is not enough space to correct or recover the ball quickly. When pressed behind and surrounded his touch will always be inconsistent, we've known this already. No point forcing it. Play him wide.