Assuming, of course, that no signings are made until the match & no one makes an early injury recovery (eg. Nani, Kagawa, Chicharito & Rafael) , I predict Moyes will go for:
-------------De Gea-------------
Jones----Rio---------Vidic---Evra
-----------Carrick---------------
----------------Cleverley--------
Valencia-----------------Welbeck
--------------Rooney------------
---------------RVP--------------
Which is, essentially, a 442. Carrick will be more withdrawn than Cleverley, & I predict Rooney will be doing a lot of work in midfield (due to Mata). However, I wouldn't be surprised if Moyes opted for 3 in midfield (Carrick, Cleverley and Giggs) and RVP up top on his own, supported by any 2 of Valencia, Welbeck and Rooney. You never know, though - after Swansea, it's hard to say that Welbeck doesn't deserve another game up front, so there is every chance he plays in a 442 up top with Van Persie.
It's strange. I mentioned 4 players who are injured for this (opening line) who would normally make the difference vs Chelsea, especially Chicharito, Rafael & Nani, yet we are still going into this extremely strong. I think we're covered in every position bar the RB for this, where I am not entirely comfortable with the idea of Jones having to go up against Hazard, Mata, or whoever else who decides to roam his way. All that said, I think we're going to win this. 2-1 is my prediction.