I feel maybe we can add Diallo to the formula, 4-3-2-1. If we have three-man midfield, pogba can definitely be in it and VDB can be on right. Diallo and Bruno can work as a floating two in-between the single forward and the midfield three. Diallo seemly has the Sancho’s ball control capability from I saw. It might work because all mid and front players can score except Fred (unfortunately).
It would require 3 man midfield. This will never happen. Notice how Ole uses his midfield - most of the time it's ONE midfielder on his own, because the second midfielder drops to the defense and third plays in-line with the strikers.
IMO Ole (or the coaching staff in general) has no clue what midfield is supposed to be doing. Whenever I see other teams play, they have midfielders doing what our defenders do (it's almost like we use CBs as playmakers).
The only setup which resembles true midfield is Fred - McTominay, because (as limited as they are) they stay in same positions all game and it provides a good platform. Second working pair was van de Beek playing in midfield, he seems to know what to do in that role.
Whenever we play Pogba or Matic in any setup it effectively leaves us with one man midfield, because the first roams* around the pitch and the second drops into back 4. Notice how big is the distance between them most of the time.
Yesterday was a good example, McTominay was dropping into defense while Pogba was high on the left. Again, 1,5 man midfield.
*the problem with Pogba is he's actually pretty useless when he doesn't roam so there's that.
I would play 3 man midfield with Matic at the base, Fred on the left and van de Beek (if we want to have structure) or Pogba on the right. That leaves us with Bruno in free role plus two strikers. But I see chances of Ole doing that close to 0, he never plays structured midfield.