It seems that McT is out? Any news?
In that case I'd go with Bruno and Fred as our pivot and VDB up front. It seems crazy but imo Bruno can be a really good 8, even as a 6. Against popular belief I'm of the opinion he can play very safely and tidy when required. And he's really good against pressing as well. He's also quite fast and has a good tackle in him.
Of course he'll be less dangerous playing there but he has some great long pass which VDB doesn't. It would benefit our fast strikers and VDB, who is pretty good with his movements into the box and scoring.
People won't like the idea of playing Bruno out of his most effective position, I don't either. But imo that's the best solution considering the available options.