Should be another 4-3-3 to test the system.
I assume Lindelöf is going to keep play as right back until Young is back from suspension. It would just cause confusion if Mourinho moved around the right back at this point.
I'd rest Jones because he's injury prone. Let Rojo and Tuanzebe play as center backs. I'd prioritize Smalling over Tuanzebe though if Smalling is back from injury simply because you want Smalling back for the Stoke match.
In midfield i'd play Pogba so that he quickly gets into the more offensive positioning of the new system. McTominay might fill in for Matic, but Matic could play because he's getting 10 days rest after the Derby game (assuming win or loss as a result). This is an important match for Man Utd so I still think it's pretty likely that Matic gets to start although he's definitely looking fatigued lately. McTominay wasn't very good against Bristol and I wouldn't trust him from start in a match like this.
In attack I wouldn't change anything because none of those players are showing signs of fatigue and they were all good against Everton.
Romero
Lindelöf - Smalling* - Rojo - Shaw
Matic* - Pogba - Herrera
Mata* - Martial - Lingard