Really torn with how we should approach this, but it is fecking Cambridge United in the end... If we can't give a few squad players or younger players a chance then there is definitely something wrong. That said, I still expect a strong starting 11 and all LvG needs to do is not play three at the back while picking players in positions that they are comfortable in.
Rafael and van Persie should probably make the bench if fit and be introduced in the second half if it's all going smoothly (pitch dependent in RvP's case as it wouldn't be worth the risk if it's bad, while we only have Leicester at Old Trafford next so he can be benched for that and come on later anyway).
I think Valdes should get a game purely because he hasn't played in ages - there will not be a better time to give him a game this season and it makes it a bit less of a worry if he had to be thrown into a big game if de Gea got an injury (as I assume Valdes will be picked ahead of Lindegaard no matter).
I think Falcao and Wilson should definitely start up front. Wilson finally bagged a goal, while Falcao is looking sharp and the goals will come (he was very unlucky to not get a couple against QPR at least). I would not be opposed to Carrick getting a rest with Blind playing at the bottom of a diamond, then pick three from Fellaini, Herrera, Di Maria, Januzaj to fill out the midfield. Rojo and Shaw need to play, with Smalling or Jones as the other CB and either one of them at Right Back or Valencia.
Rooney should be rested, but I think LvG will probably still pick him as he deems the captain's role important and won't leave out all of Rooney, Carrick, Fletcher, and van Persie for any game, even this one. The issue with this is that it probably means Rooney plays in midfield, but he should be a striker or at the top of the diamond, which would then mean it's likely Januzaj who doesn't play. I also wouldn't mind a good old 4231 with some midfielders missing out, but I somehow doubt that will happen.
What I want:
Valdes
Valencia Smalling Rojo Shaw
Blind
Herrera Di Maria
Januzaj
Wilson Falcao
What I think:
Valdes
Valencia Jones Rojo Shaw
Blind
Fellaini Di Maria
Rooney
Wilson Falcao