So lets assume that he's kicking up a fuss because he wants to play as a striker and not be shifted around as he is.
How would we accommodate both Rooney and Van Persie as strikers in the same team?
4-4-2 is the obvious choice and we'd need another strong midfielder capable of both breaking up and creating as we'd lack Rooney's craft and leg work if he's to play as a more advanced classic striker.
I'd rather see (and in all seriousness there isn't a hope of Moyes trying it...) a 4-1-2-1-2 with width supplied by the fullbacks.
Big Dave
Rafael - Central - Defender - Evra
DM
Carrick - Cleverley
Kagawa
Van Persie - Rooney
I think it'd work a treat personally but imagine United without any wingers?! Not a chance!