Turnout, probably not, opinions, in some cases yes
Say you're a Republican, as a general rule you would not normally vote for a Democrat, in your local town the fire brigade are desparate for new fire engines, somethink you agree they need, the local GOP candidate is against raising local taxes to enambe this, the local Democraat is on favor.
In this case you could vote for the Democrat on just this issue and still vote GOP for everything else, it's a gneralization but a lot of US local elections can be like this
I'm guessing you've never seen a US election ballot paper, I've seen books that are shorter than some of them!