Decisions, decisions, decisions...
I would normally go with Annah, but the combination of Rooney-Henry up front and Giggs-Ronaldo on the wings is insanely good when you play counter attacking football. So, let's see what we've got here piece by piece.
MJJ:
De Gea is an excellent choice for this kind of set up, he's one of the best in the world when he doesn't have to stray far from the goal line. He is highly concentrated and he can make unbelievable saves. Zanetti is also very good choice at RB. He's tireless, not many wingers can beat him on 1v1, i think you'll be fine there. He is also a leader, one of the three born leaders you have in your defense. As for Cole, let me have my doubts. Imo he's one of the most overrated LBs in the history of the game. He'll be the weak link in your defense, he can't cope with Muller's off the ball movement and physicality. I'd really like to know if you have plans to help him. If you plan to let him 1v1 with Muller, i can assure you, you'll be in trouble.
The pairing of Nesta and Stam is superb when you're defending deep in your box, excellent choice. Stam is a beast in aerial duels and a strong, physical presence in front of the keeper. He also earned much respect at United although Fergie's tactics often left our CBs exposed. Nesta is very clever and his positioning is exceptional in the box. They both had high concentration levels, they never hesitated and they were never afraid to make tough decisions during the game and they both were born leaders. It will be very hard to break them down if they have cover in front of them, especially when the other team doesn't have a forward with the physical abilities to annoy them, right Annah?
Which brings us to the main issue, the midfield. If you want this to be a success, then keeping your defensive shape with two narrow lines of four close to each other is a key factor. I really don't understand what you mean by saying that Keane will be all over the place trying to make it difficult for the opposition and steal the ball. People mention yesterday's game and how Real Madrid coped with Pep's tactics. I'll use the same example: I didn't see Alonso and Modric moving out of position and chase the ball. Their main focus was to narrow the spaces and protect the channels in front of the CBs. Team cohesion is a must here.
Otherwise, your midfield choices have many pluses. I don't share the others' worries about Fabregas' defensive contribution. He can play deeper, as he can hold the ball, he can run with it through the middle and his vision is great. Keane is great DM, especially when it comes to closing down opponents, stealing balls and regaining possession. In his prime he could also run with the ball through the midfield and that's a bonus for you which not even Real Madrid had in yesterday's game with Alonso.
Giggs and Ronaldo are as good as it gets on the wings and Rooney-Henry can create lots of problems whenever they find open spaces.
Annahnomoss
Valdes is a good choice for this style of football, he's good with the ball and confident when he must leave his box.
Lahm and Abidal are also very good choices. In my eyes Lahm is the most complete full back in the world, right now, a very balanced player. He can defend, he can do overlaps-underlaps and participate in the attacking moves and he can pass or cross the ball pretty well. Abidal is exactly how you described him. I suppose you'll use him more as a third CB when needed.
I guess neither Pique nor Puyol were available at CB. You have made a good choice with Silva. He's world class, one of the very few CBs who can defend with confidence outside their box. I can't say the same about Cannavaro unfortunately. I always remember him, and the other great Italian defenders of his generation, for defending superbly in the box, playing for sides which chose to defend deep and fought to keep a clean sheet at all costs. I can't remember him playing in a high defense line. I believe he will be exposed against a side with so much pace. I know i'll get the stick from many people here, but i simply don't believe he's fast enough to play in this team. If Henry and Rooney "mark" him and try to find themselves in 1v1 situations against him you'll be dead before you know it.
So, we come to the main point. They'll be times when the 6 sec. rule won't work. What will you do when MJJ's team manage to get the ball out of their third and hit on the counter? If Giggs, Ronaldo, Rooney and Henry find themselves in the attacking third, they'll have the advantage even if Abidal stays back to cover for Lahm (who'll be doing the overlaps) and Busquets drops deeper. It will still be 4 attackers vs 4 defenders (4 chances for 1v1), that's pretty much the reason Bayern were annihilated yesterday.
Don't tell me this is Barca of 09-11, i know that. Find me that extra defender whenever MJJ hits you on the counter, a proper cover for Cannavaro and my vote will be yours.