I said elsewhere that Djokovic's defeat today could improve his US Open chances. Now he will not go into that tournament, surrounded the by the pressure and frenzy of potentially securing the calendar grand slam, like in 2021, and so could play more freely. Alcaraz as the defending champion and on the back of today's success will be the clear favourite. Djokovic faced more pressure in the 2021 US Open final and at that tournament as a whole, than Federer or Nadal have ever faced in any match or tournament during their careers. That's because a calendar grand slam bid is on a different level, compared to trying to win a record number of grand slam titles overall (if you fail there you always have the next grand slam, the one after that etc. to try and do it), or at any at any individual grand slam, or even trying to secure a 'non-calendar' 4 in a row sequence.
If I was in Djokovic's shoes (unfortunately I have to settle for playing tennis in my nearby park), and I could choose one more grand slam title to win, I'd definitely choose another US Open title over any other. That's the one grand slam where you can argue that he has 'underachieved 'at during his career given his ability on hard courts (though 3 titles is still excellent), and where he has some unfinished business (especially after what happened in 2020, the defeat in 2021, not being able to play there last year etc.).