Very much doubt Messi will have a goalscoring cakewalk in the PL as all the attention will be on him and every team and every defensive player on and around him will see it as the pinnacle of their career to try and stop him - not that they necessarily can, but with his age and slowing down, him being up for all that hustle and bustle in the pursuit of goals is, I think, less likely than his assist numbers going even higher.. Double and triple teams are inevitable, what should happen in the meantime, however, is him finding a bazillion ways to slot others in who will be in acres of space due to his mere presence elsewhere on the pitch.
Unless City switch to a 4-4-2 or 3-5-2, Aguero's about to lose his spot, I think... the RWF position seems to be mentioned for Messi in association with the main body of his work, but that move into the centre of the pitch is looming, and Pep won't have that lack of graft out on a flank otherwise De Bruyne would be compromised or in need of moving for a CM minder for Messi, which is not Pep's style.
It all depends how Guardiola deploys Messi, really. City's team is well drilled, they have clear patterns in the build up and organized runs in the attack. Messi hasn' had a team like that since at least 2015, probably even 2013 which has lots and lots to do with him dropping deeper and deeper in recent years. In Barcelona's prime years, Messi could focus on the final third and was incredibly hard to mark due to his false 9 movement. Wide forwards making deep runs and him dropping into the half spaces always ensured that somebody could find him with a pass between the lines. It'll be interesting to see if he can at least somewhat reproduce his output in such a team. City definitely don't need him to initiate attacks from deep like Barca did in the last years.
What's probably even more interesting is the question how Messi's integration would affect de Bruyne's playing style. Right now he's occupying lots of spaces Messi likes to operate in. And de Bruyne also has the privilege to lose lots and lots of balls. I think if Messi really joins City, Guardiola will ask de Bruyne to play less risky.