Of course we'd miss them. Every team in Europe would struggle if their two left backs and left centre back were to get injured, regardless of squad depth.
Let's have a look at the top three in the EPL, as they possibly have the strongest squads:
Arsenal
White/Timber - Salbiba/White - Gabriel/Kiwior - Zincheko/Kiwior
Cedric and Tomiyasu
Man City
Walker/Lewis - Dias/Stones - Akanji/Ake - Gvardiol/Ake
Gomez
Liverpool
TAA/Gomez - Konate/Matip - Quansah/Van Dijk - Robertson/Tsimikas
Bradley
Man Utd
Dalot/Wan-Bissaka - Varane/Maguire - Lindelof/Martinez - Shaw/Malacia
Kambwala and Evans
Now, as I said before, I get that Shaw is injury prone, and maybe it is time to part ways with him, but no one would have foreseen the amount of injuries we've had put up with, especially in the same area, and as you can see above, any team would struggle if they had to put up with that.
Going into next season, I think a RCB and LB will be enough.