Massive Spanner
The Football Wrench
You all have mentioned pretty much every big acting performance in the history of cinema, I'll just throw in some rather not very well known (or well thought of ) ones that spring to mind
Laura Dern in Wild at Heart
Willem Dafoe in The Last Temptation of Christ
John C. Reilly (Magnolia)
Jodie Foster (Contact)
Richard Farnsworth (The Straight Story)
Bryce Dallas Howard (The Village)
Heh, I'd hardly consider them great.