Always tough to predict a line up when you don't know the availability of the likes of Shaw, McTominay, Sancho, Martial. Or Eriksen, now.
I tend to prefer rotation within moderation - only resting players who need it, and who we have competent replacements for. Although with games coming thick and fast, injuries mounting, and going into the game with a 3-0 lead, then I'd probably go a little weaker than usual or that I'm comfortable with.
Assuming the above players are all unavailable for Wednesday, then I'd go with something like...
Heaton
Wan-Bissaka
Maguire
Martinez
Malacia
Casemiro
Fred
Pellistri
Antony
Garnacho
Weghorst
Bruno and Rashford on the bench if needed. But hopefully not and we can give decent time to Mainoo and Elanga instead while subbing off Casimero and Weghorst. Hopefully some of the listed 'unavailable 5' will actually be available as well.