I don't think any of those other seasons saw as many players leaving as this season though.
You'll have to forgive me on an uncertainty on whether I should count a person as a first teamer and/or a loan as important enough to mention, but following the same strategy as my previous list of ins, here's the outs (again, brackets means either a loan, a backup keeper or a less notable sale):
22/23 - 5+ - Lingard, Matic, Pogba, Cavani, Mata (Grant, Pereira, Henderson loan, Telles loan)
21/22 - 1+ - James (Periera loan, Tuanzebe loan, Romero)
20/21 - 4+ - Smalling, Dalot, Rojo, Sanchez (Lingard loan, Ighalo end of loan)
19/20 - 5+ - Lukaku, Darmian, Young, Valencia, Herrera (Wilson, Smalling loan, Rojo loan)
18/19 - 3+ - Blind, Fellaini, Carrick (Johnstone)
17/18 - 4+ - Mkhi, Januzaj, Ibra, Rooney (Pereira loan, Wilson loan)
16/17 - 3+ - Schneiderlin, Depay, Schweinsteiger (Januzaj loan, McNair, Blackett, Keane, Valdes)
15/16 - 7+ - Di Maria, Chicharito, Evans, RVP, Nani, Rafael, Cleverley (Lindegaard, Amos, Januzaj loan, Wilson loan, Blackett loan, Keane loan, Powell loan, Milinkovic-Savic, Henriquez)
14/15 - 10+ - Welbeck, Kagawa, Buttner, Zaha, Evra, Vidic, Rio, Fletcher, Anderson, Giggs, (Bebé, Chicharito loan, Lingard loan, Nani loan, Amos loan, Cleverley loan, Petrucci, Macheda)
13/14 - 2+ - Scholes, Fabio (Zaha loan, Anderson loan)
12/13 - 3+ - Berbatov, Park, Owen (Kuzczak, Fabio loan)
11/12 - 6+ - O'Shea, Obertan, Brown, Hargreaves, Scholes, VDS (Diouf, Gibson, Bebé loan)
I mean I could keep going but the point is we lose a lot of players more often than you think. The problem with the situation we have right now is that the sheer volume of losses in midfield and attack, and a lack of up-and-coming talent to replace them from youth ranks. But hey, I didn't really know about Rashford until he was given a start, so who knows, maybe we'll see Garnacho or someone similar storm into the side and make us think we were silly to worry in the first place.
Regarding Martial, that's massively gutting and I figure we're signing a striker regardless of his injury, but it'll be a strain on our earlier games of the season with I'm guessing Amad/Garnacho coming into the squad as subs.
Again, will judge our transfer window once deadline day has ended.