Got to find that angle.
The vaccines | vaxxed boosted unvaxxed? New poll
- Thread starter Badunk
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Got to find that angle.
I'm just going off what the CEO of Pfizer said
https://www.theguardian.com/world/2...d-jabs-after-claims-of-bowing-to-anti-vaxxers
What is the reason for the anger then?
Partly, but a bigger issue is probably the fact that Astra Zeneca was expected to be approved by now. I don't think Pfizer anticipated being more or less the only high volume supplier in the EU at this point.
The production ramp up has been extraordinarily fast, particularly for a product that requires specialist storage and handling at the plant, through filling and into distribution.
Not really. The biggest factor in unanticipated increase in demands on Pfizer most likely the shambolic Oxford vaccine development program. If they had hit their anticipated approval timelines that would take a lot of pressure off Pfizer. Moderna struggling to ramp up their manufacturing isn’t helping.
I can totally understand Pfizer's reason and it makes sense long term but I can understand why a lot of countries are going to be upset too, especially if their strategies depended on the numbers that Pfizer had guaranteed for that particular quarter.
Thanks.
What happened with the Oxford approval program?
Worth noting that because of issues Pfizer had already scaling up their production capabilities, the UK ended up receiving 4 million? doses by the end of 2020, rather than the 10 they seemed to think they were getting.
Let's hope this resolves the issue as much as possible for 2021.
Let's hope this resolves the issue as much as possible for 2021.
I dont see that here. We are doing fine in Italy, over a million doses given in 2 weeks.
I suspect theres an element of individual countries trying to pass the blame for their own screwups.
Thanks for the interesting information. As far as I know, there is very little evidence regarding the stimulation of IgA production by nasal spray vaccines (not only against SARS-CoV-2). Even if they do, IgA only provides a transient protection as it is known for its short half life. The only way a vaccine can provide a long term protection is to trigger immune responses in blood and let the memory immune cells recognize the antigen.
They ran their studies in a fairly chaotic way. With significant differences in dosing regime and patient population in sites in different countries. Which causes a headache when it comes to combining all the data for regulatory approval. It’s why they’re taking much longer than the Pfizer/Moderna vaccines to go through that process.
I mentioned this specifically in the context of preventing infection. Theoretically a strong IgA response is what stops the virus getting a foothold (nosehold) in your body in the first place. They do have a short half but, just like systemic Abs, you can induce a ‘’memory” which help them respond more effectively if they meet the same antigen again in the future.
Obviously, you also want a vaccine to trigger a systemic immune response. In case the vaccines gets past those initial defences. Which intranasal vaccines will do as well.
Grandparents both had their second Pfizer vaccine last Sunday. The family has had a collective sigh of relief, particularly as my Grandma has quite bad asthma (and both are in their mid 80's).
Is it around 1-2 weeks after the second vaccination that it takes full effect? They're desperate to get out of the house (even to go to a supermarket) at this point.
Is it around 1-2 weeks after the second vaccination that it takes full effect? They're desperate to get out of the house (even to go to a supermarket) at this point.
Thanks
This is a decent article on the UK story so far, good and bad.
https://www.politico.eu/article/8-reasons-why-uk-leads-europe-coronavirus-vaccination-race/
Sounds right but I just vaguely remembered some potential benefit.
When push comes to shove we just need to vaccinate as many people as fast as possible. I've had my sleeve rolled up for weeks
That is great news. I seem to remember 7 days after the second shot maximum immunity was recorded. But don't take my word/memory as gospel.
Absolutely, it's pretty incredible to have people vaccinated 9 months after the first lockdown.
That's great news, can totally understand that you're all quite relieved! My grandparents are 90 and 88 but are only scheduled to get their first one somewhere around March (and probably later, given our government's failures). Especially frustrating since we can't get my granddad to stay inside the house
That's great news, can totally understand that you're all quite relieved! My grandparents are 90 and 88 but are only scheduled to get their first one somewhere around March (and probably later, given our government's failures). Especially frustrating since we can't get my granddad to stay inside the house
We were quite lucky as they were desperate to mix with us as part of the 3 families on Christmas day, but with their vaccines scheduled we managed to convince them that for the sake of a few weeks it would be crazy to risk throwing 9 months away.
Just me a bit fed up of these stories? I don't think the media have been that doomongering as claimed during the pandemic but I find this constant stream of this % not wanting to apparently take the vaccine from a random pool a bit frustrating when we're seeing daily coverage now of over 80s pretty much queueing round the block to get their jab which is brilliant and I commend them.
Pretty happy we're already at 5% of whole population and take has been very high in a fair few regions so hopefully we'll get to the 15m point sometime in February and slowly unlock from there every month.
That’s what you would expect from the same research in fairness.
There are groups that were expected to take it in very high numbers. They just happen to be first. There are other groups that are expected to be more hesitant, and public health officials need to invest a lot of time to persuade them them. Being alert to that and taking action to address it - including raising public awareness - is important. Being conscious of legitimate challenges is not doom mongering.
Mrs F-Red got her first vaccine yesterday (Pfizer), no side effects at all. Second one was booked there & then for 12 weeks time in April.
Over 70’s and those identified as Clinically Extremely Vulnerable to begin receiving letters from tomorrow.
The aim of having all adults jabbed up by September doesn’t give me much confidence in the various sporting events I have tickets for over the summer.
We all have seen plenty of news about the side effects of the vaccines. Actually, what is the rate of adverse effects, and is it significantly higher than that of routine vaccines?
Didn't I read that half of over 80s were vaccinated? and they are moving to over 70s ? What about the other half? Not keen on getting a vaccine?
Very low. I think the US has only had 21 significant allergic events (from memory) from 2 million vaccinations. 71% occurred during the 15 min supervision period and all recovered fine.
They’ll be some overlap between priority groups. Letters are obviously sent out in advance of appointment times etc.
Plus, some GP’s/hubs are slightly ahead too - though from what I read they’re trying to avoid too much disparity across the country. But anywhere that has spare capacity will be encouraged to move on to the the next priority group.
Just to update this for those interested, his full test did indeed come back positive. So for him, the first jab didn't prevent him getting it. The home he works at has a bad outbreak so whether that played a part I don't know. If the first jab only protects you 50% as first stated its not too surprising.
Re side effects. We had our whole home vaccinated with the Oxford including staff for those who hadn't had the Pfizer jab. Quite a lot of people getting side effects, a day or 2 of fluey symptoms. However, I would not be too surprised if a lot of it is a bit of mass hysteria. I had the second Pfizer jab last Monday and had no reaction, maybe a little drowsy but fine.
My other half's parents got their invitations over the weekend, both early 70s. NW Manchester based. Listening to a radio phone in this morning there's a lot of 80 year olds phoning in saying they've not got their invitations yet. Seems patchy by local authority at the moment.
That's what I'm thinking. Local media here keep exaggerating these rare events and make the vaccines sound unsafe. Pretty sure many would take that story and refuse to get vaccinated.
Hmm. India have vaccinated 200k and reported 447 adverse reactions.
Getting the Oxford one and another one which is still in phase 3 trial.. but they might be classifying it differently.
Will be a load of people feeling sick because they expect to get sick. My old man was director of buildings at a university and told me a story about when they were treating all the plants in a block of offices with pesticide overnight. It was all deemed to be completely safe but they sent a letter to all the staff telling them what was happening and advising them to keep a window open the next day. The following day dozens of people called in sick with headaches and nausea and he got a load of emails complaining about the toxic pesticide. It gave him great pleasure to let them know the pesticide guy hadn’t turned up and none of the plants had been sprayed!
So couple of rumours I've picked up this weekend. Johnson and Johnsons single shot vaccine is 100% effective and there is a study of US students to be published who caught covid, regardless of symptoms, 60% developed heart issues. See if these come true in the coming weeks.
That includes all of the minor reactions like a sore arm, slight fever and the like. They had 3 hispitalised cases and the reporting doesn't make it clear if these were allergic reactions or just hospitalisations of people who happened to have been given the vaccine.
Friends in Hong Kong (i used to live there) say you will be getting the Chinese vaccine too, so knowing the media there that is probably a factor. Some will be trying to discredit the Western vaccines.
My son is at Uni in California and he knows lots of young people who have had covid with he hasn't heard of anyone getting a heart condition. Obviously far from scientific sampling and I'm sure it is a genuine concern, but 60% sounds way too high.
If it is also sterilising street parties are in order.
Their phasec1/2 data showed 100% effectiveness from a single shot in the 18-55 aged groups and it was neutralising (which I think means the same as sterilising). I think they are due to report their topline phase 3 data soon so fingers crossed.
https://www.jnj.com/johnson-johnson...-published-in-new-england-journal-of-medicine
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Like a good boy, I've just had mine.
Pfizer.
Pfizer.