Ahh, that explains it! Definitely reassuring in that case.
The vaccines | vaxxed boosted unvaxxed? New poll
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Ahh, that explains it! Definitely reassuring in that case.
Moderna update on duration of response from Phase I subjects. 119 days and counting. Admittedly, persistence of antibodies doesn’t necessarily mean persistence of immunity but great news all the same.
I thought that was a quite obvious statement, the distribution of the vaccine won't really truly hit volume until late Jan/Feb, by which case you're at the mid-point of winter admissions.
Given some of the hesitation by some to take the new vaccines, these pioneering people are heroic!
I think maybe the people that volunteered to take part in the trials deserve a shout as well.
The beginning of the end of covid19!
British citizen Margaret Keenan, aged 90, first person in the world to receive approved vaccines.
8 billion people to go!
Looks like I’ll be one of the last people in Ireland to get the jab!
Interesting that they bumped 18-34 year olds up the queue on the basis that their social lives put them at increased risk.
Interesting that they bumped 18-34 year olds up the queue on the basis that their social lives put them at increased risk.
as part of tests, not as an approved drug.
Matt Hancock getting 'emotional' (with added jingoism), if that's what it was, at the amazingly named William Shakespeare being the second person to get the jab, was odd.
Even by that logic she's not the first in the world since Russia have been vaccinating people too with an approved vaccine.
I feel like giving a 90 year old woman the first jab is such a bad idea. At that age there’s a good chance that on any day of the week, no matter how good her health is, she could have less than a month left to live.
If she dies in the next few months, it’s going to be red meat for the anti-vaxx parade
If she dies in the next few months, it’s going to be red meat for the anti-vaxx parade
Data from Pfizer shows that protection seems to start within a couple of weeks from jab 1. Still need jab 2 for long-term protection, but that's good news for getting things under control sooner.
i was waikting for this - any of it to be frank. so far the press releases have talked about the downstream effect (contracting covid), i wanted to see if they were also looking at mechanism. this is good.
That’s the difference between Phase I/II and Phase III studies. In the earlier phase studies you can look at biomarkers or proxy measures (e.g. antibody production) but Phase III trials need to look at hard clinical outcomes (disease vs no disease) The study in that tweet is long term follow up of a Phase I cohort.
Mind you, it’s not uncommon for Phase III trials to also look at biomarkers as secondary or tertiary endpoints. You probably won’t get to see those until the publication.
Did the kid from breaking bad get fat?
You know you’ve made a proper tit of yourself on Twitter when Ben Shapiro corrects your logic.
Any news on adverse reactions when being injected with SpunkIt? Surely stories would have leaked by now?
"Three cases of transverse myelitis were initially reported as suspected unexpected serious adverse reactions, with two in the ChAdOx1 nCoV-19 vaccine study arm, triggering a study pause for careful review in each case. Independent clinical review of these cases has indicated that one in the experimental group and one in the control group are unlikely to be related to study interventions, but a relationship remained possible in the third case. "
from the oxford vaccine paper today.. isn’t this alarming?
from the oxford vaccine paper today.. isn’t this alarming?
I'm not so sure its that alarming. Transverse myelitis is pretty complex disease in terms of aetiology. Vaccinations, viral infections have been suspected but 60% are idiopathic. But there might be a possibility of increase risk, we've seen vaccines increase
Here is the full paper for anyone concerned
https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620326611.pdf
There's been plenty of suspected neurological issues related to vaccines that after longer term data were considered unlikely (hep B with multiple sclerosis, GBS with meningococcal vaccine, H1N1 influenza vaccine with narcolepsy, anthrax vaccine with squalene adjuvant for Gulf War Syndrome) but famously I believe the 1976 vaccine swine flu vaccine was found to have had increased risk of GBS so its not impossible either.
Thanks for link to paper. A few weaknesses immediately obvious (in addition to previously discussed stuff around “serendipitous dosing” and combining data from different trials, with different methodologies)
The timing of the booster dose was highly variable because they only decided to add a booster after the trial was underway and couldn’t manufacture it fast enough to give it a standard time after first dose. So they were getting the second dose anything from 4 weeks up to 12 weeks later.
That’s just one of a whole bunch of protocol amendments with the study already underway. Which is not ideal.
They get brownie points for at least checking for asymptomatic spread (unlike Pfizer/Moderna) but, unfortunately, didn’t seem to stop it.
That’s on a quick scan. Be interested to hear your thoughts (or any other medics) I think this was the first trial to get started and it shows. I suspect there will be a lot of back and forth with the regulators before this gets approved.
I think so, but no doubt usual suspects will disagree,
Would very much like to know what the side effects are of these vaccines.
A far bigger shout!
Not going to lie, I'm quite glad we probably won't be getting much of the Oxford vaccine here.
Not sure where you are from but at the moment the Oxford vaccine is the best hope for most of the world
There's something vaguely unsatisfying about that Oxford/Astra Zeneca report. I know some of it is inevitable in that it includes various protocol changes and rationalisations about how to combine/present data. It's also frustrating not to have a little more detail on the neurological incidents - I understand that I'm probably being unrealistic about that, but still - the reasons for discarding them may be clear to the neurologists, but I still feel the public defence in the report needed to be stronger, if only because of the bad PR.
I can't help but think the report, and maybe even chunks of the actual research/trial will need more work before approval in the US. I assume they're currently assembling/presenting more data and answering questions from the MHRA as well. It's unfortunate though, a lot of countries are banking on the Astra Zeneca vaccine for high volume in Q1 - and I do wonder if we're looking (at least) at a significant delay.
I can't help but think the report, and maybe even chunks of the actual research/trial will need more work before approval in the US. I assume they're currently assembling/presenting more data and answering questions from the MHRA as well. It's unfortunate though, a lot of countries are banking on the Astra Zeneca vaccine for high volume in Q1 - and I do wonder if we're looking (at least) at a significant delay.
Europe. In Q1 we will have 300m Pfizer doses and 100m or so from Moderna.
Which countries other than India?
Australia will need to use significant quantities of it.
I see. How do you feel about the info published? Would you feel comfortable taking the oxford jab?
I'd have it without a second thought as I would with any of them. The mRNA ones are more effective so I'd opt for them if I had a choice be I doubt many of us will be able to pick and choose.
Is there any set (or rough provisional) date as to when mainland Europe are starting to vaccinate?