Not just preventing death but preventing severe symptoms and hospitalisation
Edit: In addition the oxford vaccine has evidence of preventing transmission as well, evidenced by lower transmission rate, even asymptomatic infection in the vaccine arm
The vaccines | vaxxed boosted unvaxxed? New poll
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Not just preventing death but preventing severe symptoms and hospitalisation
Edit: In addition the oxford vaccine has evidence of preventing transmission as well, evidenced by lower transmission rate, even asymptomatic infection in the vaccine arm
But this is wrong isn’t it? You’d still carry the virus!
am I wrong here or is everyone who is saying to protect others and create herd immunity wrong?
quite worrying if people think they’re getting the vaccine to protect others if it doesn’t actually protect others and they can still catch it off you. Cases are going to rise massively if everyone is walking around thinking they can’t pass it on
It’s effective at preventing symptomatic infection; death wasn’t the end point of the trial, symptoms of Covid-19 followed by a positive test were. This won’t detect asymptomatic cases, but long Covid will be much rarer in this group.
Worrying isn't always a rational thing. She may feel that being part of the first group is like being in a clinical trial but without the support. Personally, I doubt that will happen - these early users will be watched like hawks.
If it's the ten months v ten years idea then I don't take that one as seriously as some people do - most of those years are spent on pause, waiting for the next batch of funds, or the next hundred trial volunteers. Most actual complications/side effects are revealed soon after the vaccination.
What you can't see in trials are the rarities, the ones that happen 1:50000 cases etc - where some combination of genetics, pre-existing conditions, medications etc could mean some people react differently. They could monitor the current trial groups for the next ten years and they still won't see those - or for the next thirty if you want to see the affect on children born post-vaccination.
Personally, I can't do the next ten years locked in, so I'm in one of the clinical trials to try and help push the process along. We all have to decide where to draw the line.
I envy you guys in the UK. We in India will get the vaccine god knows when.
It'll be fecking funny watching people actively decline the vaccine. Dumbfecks.
First world problems init.
It'll be fecking funny watching people actively decline the vaccine. Dumbfecks.
First world problems init.
Great news that should bring us back some normality. I'm not planning to get vaccinated but probably would if I had to for the purpose of travelling although I don't think countries are going to push for that, at least I hope not. That seems to be the view of most of my friends and people around me I've talked to.
Thanks for this, will try and use some of this to put her at ease, I completely understand why she feels the way she does! Like you said she probably feels like she’s the first one on the front line.
Amazing. Sign me up.
This is the best news I have seen this whole year 
. How did we get to this position so quick? Early in the year, I was thought to believe that it was near enough impossible to have a vaccine that would be tested sufficiently that it could be rolled out now.
So once people have the vaccine what are the main things we will be looking at to give us an idea of how effective it is?
. How did we get to this position so quick? Early in the year, I was thought to believe that it was near enough impossible to have a vaccine that would be tested sufficiently that it could be rolled out now.So once people have the vaccine what are the main things we will be looking at to give us an idea of how effective it is?
Long covid will be completely nonexistent in the asymptomatic group. If you don’t get any symptoms to begin with then you can have persistent, long-term symptoms (which is basically what “long covid” is).
Apart from everything already mentioned, it may be mandatory for travel to certain countries in the coming years.
My wife is doing the same I am happy about her caution. I am worried this vaccine may be rush, and obviously hope to be wrong.
If you have this first vaccine will you be ok to have the Oxford one when it becomes available as well as that sounds fantastic preventing transmission to others .
I understand why people feel that way, but as the poster I quoted before said it doesn’t seem to have been rushed at all? I am happy to be corrected but I am under the impression it has essentially been pushed to the front of the queue and has the funding needed to develop quicker, it’s off the back of years of research and had the same amount of trials others have had. They will constantly monitor it and never stop researching into its effects.
I understand why people feel this way as I think on some level I do too! But I’m not even sure why.
With health service staff being vaccinated first it will be interesting to see what the vaccine acceptance rate in the industry is. These people know a thing or two about vaccines.
The companies in question have nothing to gain by rolling out an unsafe vaccine, short-term profits are no good when you're going bankrupt in the long run because of a bad vaccine.
Neither do instances like the CDC or EMA, why would they put their reputation on the line? They have nothing to gain by giving out a false positive judgment.
Nah I think two doses from one vaccine will be the aim
To be honest I think this Pfizer vaccine will be given to the elderly, care home staff and residents plus some frontline clinical staff which will run through most of January to February probably for two doses.
By which time the Oxford vaccine will hopefully get the regulatory approval, maybe Moderna as well. But we'll have established proper infrastructure hopefully to roll things out. Will be a massive challenge though, vaccination centres need army recruiting and volunteers from clinical staff. I'd gladly offer my time to administer it for free.
Will be interesting if all three are approved, which is the chosen one that is given en-masse. Oxford will the easiest logistically and cheapest
Has this been approved elsewhere ? Any other countries rolling it out at the same time?
Thanks , Oxford sounds the best if it prevents transmission too, it would be good to know you can`t infect someone elderly.
I know so many of my colleagues in the NHS who are actually saying right now that they won't take it which is weird considering we always criticise people who don't other vaccines. Unfortunately it's the age of misinformation and somehow people have started to believe that NHS is being used as guinea pigs which is an utterly ridiculous way to think about it
Nope. UK seems to have got there ahead of everyone else. I’d love to know how/why.
Yep, I hope we`ve got it right and haven`t jumped the gun. I find it very strange that no one else is going for it especially the US or Belgium as they developed it didn`t they?
Belgium (and all other EU countries) are waiting for the centralised regulator, the EMEA, to give a license for all EU countries simultaneously. Usually the UK would do the same. You have to wonder if there’s some Brexit-related posturing in beating the EU to the punch!
I don’t think this is true. I understand it will be a small minority, but it is possible to have asymptomatic infection with the live virus and suffer effects at a later date.
My cousin had no symptoms initially, but they are now linking her lung problems to a previous undiagnosed asymptomatic case of Covid.
The other two probably do as well, we'll know for sure more with bigger sample sizes once roll out happens
But main thing is that its safe, effective in a clinically significant way (preventing severe disease across all age groups)
You may have a point there.
Oh nice one. Yes let’s speculate that the MHRA has approved it to score political points. How churlish can you get.
Dry your eyes. Anyway, turns out this has already been discussed. Hancock tried to claim that Brexit sped the process up but the MHRA pointed out that the relevant legislation has nothing to do with Brexit.
Good research is sparse I think but King's College studied the covid symptom study app and found this.
https://www.kcl.ac.uk/news/study-identifies-those-most-risk-long-covid
Being overweight and asthmatic also increased risk
Because there's a batch of stuff with the UK's name on it sitting in Belgium.
Pfizer only sent through their EMEA approval request this week - basically I think because they aren't allocating much stuff to the EU pre-Christmas. The MHRC request is a couple of weeks older.
The US review meeting is scheduled for next week. I believe it's a less centralised group and that it's also examining the manufacturing process as it scales up to mass production as well as the batch production used to create the early shipment quantity. Whether that justifies the respective timelines, I don't know.
Are you sure about that? First time I’ve ever heard of license application being linked to manufacturing timelines. They’ve nothing to lose with getting a license if they don’t have drug to supply but it’s a huge risk to delay the application - for any reason at all - as the regulators could ask unexpected questions which push out the approval timeline by weeks/months.
Much more likely that the various regulators have different expectations re the content of the application/review process. I’m sure Pfizer want this approved as quick as humanly possible, in every major territory (might stall in smaller territories if they haven’t the regulatory resources to spare)
I think its more about how the UK has fecked things up with the pandemic with high number of deaths, cases, unpopular tier system in addition to scandals with provision of services and probably corrupt profiteering.
Think they might have done their best in that regard to speed things up to give some good news and take some of the heat off.
What might make things interesting is if another comparable regulator in EU or elsewhere, for whatever reason, declines or postpones approval of the pfizer vaccine or other vaccine that might be approved here in terms of how that story will be portrayed in terms of confidence in the vaccines
I assume that they prioritised the paperwork for the US and the UK authorities. I'm not sure why EMA needed a different set but certainly the formal application for final review only went in yesterday.
https://www.ema.europa.eu/en/news/e...-authorisation-covid-19-mrna-vaccine-bnt162b2
The US one I think was submitted at the same time as the UK application (20th November). So either the MHRA are faster than the FDA (possible) or the FDA have more material to analyse. I believe they include manufacturing process/QC in their emergency approval application - so not so much about the manufacturing timeline more about manufacturing sites and how batches get certified. Not usually an issue for emergency use applicants (who carry on making trial size batches) but the scale of this is very different to normal.
I think a proportion of medial staff, although happy for the development, are concerned about being the "guinea pigs".
The person administering the vaccine has to observe the subject for 15 minutes after injection and be trained to identify various adverse effects. Which some may interpret as then being extra safe, others may wonder just why this is required for this particular vaccine.
Ultimately it should be down to individual choice.
I read somewhere that it’s because of Brexit. Since you are, soon to be, all on your own, you don’t have to wait for the EU to make decisions for you. Even Norway, who isn’t part of the EU have to wait for an EU vaccine-approval because of the EEA.
Yes you’re right of course! Though there could exist some cases to the contrary, as Covid-19 asymptomaticity seems to be poorly understood.
https://www.ft.com/content/021720c2-157e-40b4-b2f9-33515032fb19 - should go someway to explain the how.
It is not clear at this point whether the vaccine stops you passing the Covid virus on. All that is known is that it has a high level of protection against you catching the virus.
Highly likely lots of places will approve very soon so it may just be that someone had to be first by a few days or even a week or two.
I'd also like to bet that before we are much older this approval will be touted as a benefit of Brexit. Both and his evil clown posse won't be able to help themselves.
One other major benefit is that this is that mass vaccination, preferably every single person who can, is the only way back to something close to normal. Getting the canopy back on track will save lives and improve physical and mental health and normal medical services will be able to operate normally which will have the same effects.
We are in fact in this together even if you don't want to be. We all have to take one for the team.
We are in fact in this together even if you don't want to be. We all have to take one for the team.