Yep, lots of chess-like moving parts in the raid so Oda can be quite flexible in terms of matchups, and easily swap multiple parties in and out of brief skirmishes. King and Jack are definite concerns, and need to be prioritized by the best-of-the-rest from the lower levels — at face value, and from a power-scaling perspective, a mini-alliance of Marco (the ability to fly is going to be crucial even in a slightly weakened state, but is he going to involve himself in an overt way?) + X-Drake (stepping up from the Tobi Roppo) + remnants of the Worst Generation or other allies should suffice by the finest of margins, but you never quite know how things will shake up, do you?
As regards Queen, I really-really hope that he faces Sanji (once he evades Black Maria that is). Like, the guy specifically mentions ‟Judge's son” and seems to be a master of mechanical modifications, so there's some sort of history there involving him, the Vinsmokes and possibly Vegapunk — and Sanji overcoming him would be a seminal/character-defining event, on top of crystallizing him as a bona fide Yonko commander level character in the post-Wano period.
And yeah, definitely feels like an uphill battle as the Yonko are portrayed as overwhelming forces of nature — completely different echelon vis-à-vis the likes of Katakuri/Doflamingo...and lest we forget, not too long ago, Luffy was one-shotted and Kid held captive. Our protagonists couldn't possibly have improved that much in a short period of time? Squeaky bum time, I suppose...