We'd use him in either a 4-2-3-1, 4-3-3 or 4-3-1-2:
De Gea
AWB Maguire Lindelof Shaw
Lingard McTominay Pogba
Dybala
Martial Rashford
De Gea
AWB Maguire Lindelof Shaw
McTominay Pogba
Lingard Dybala Martial
Rashford
De Gea
AWB Maguire Lindelof Shaw
Lingard McTominay Pogba
Dybala Rashford Martial
Assuming McTominay is our defensive mid and Pogba is the #8 (Dybala has no impact on that, neither does he have any impact on where Martial or Rashford play). The main rotation option will be what I put Lingard as. Easier games, he probably goes in that front 4 to balance out the attacking nature of the other 3 with a more midfield, industrious and link up type approach (can also see James rotating with Lingard in that role). In a midfield 3 in tough games can put McTominay as box to box, swap Lingard for Matic as holding mid (or another more defensive/controlling type of midfielder), Pogba in a more free role and have the front 3 fluid, 2 wide forwards with one dropping deep or split strikers like last season with Dybala roaming behind or whatever else. Options are there, and it's pretty seemless to get Dybala in his strongest position without negatively impacting Pogba/Martial/Rashford based on anything we've seen under Solskjaer and how he'll set us up (which is in a 4-2-3-1, 4-3-3 or 4-3-1-2).
The worry is we don't have the right balance in midfield to make it work with McTominay next to Pogba, but that's not really changed by signing Dybala or not signing Dybala, nor would Bruno Fernandes change that (since people on here clearly have the completely wrong image of what he actually is as a player - not a midfielder, more a Kagawa type in terms of positioning..). That's only being changed if McTominay steps up (think he might), or we sign a top defensive mid that can balance Pogba (and Pogba improves defensively).
- Martial - Rashford - Dybala with Pogba in midfield;
- Aubameyang - Lacazette - Pepe with Ceballos in midfield;
- Sane - Aguero - Sterling with Silva/Silva + KdB in midfield;
- Mane - Firmino - Salah with Keita/Ox in midfield;
- Willian - Whoever - Pulisic with Barkley in midfield;
- Alli - Kane - Son - Eriksen;
- Or look at Fergie sides -> Ronaldo, Rooney, Tevez, Giggs, Scholes all in the same side
It's the same balance for everyone. Some teams might have some more industrious players, some are virtually the same in terms of actual defensive output, some just had coaches turn those very same players into harder workers defensively. Having an attacking front 3 with a creative midfielder is pretty standard, and the other 2 usually balance that out a little. Pogba is unique in that he can provide the defensive balance at times, just lacks consistency massively with that side of things. There's a lot of set ups to make it work, but Dybala really doesn't unbalance us at all IMO.