You're facing a good team with some great matchups... The Bills give up a ton of rushing TDs, and his Panthers face Atlanta's awful defense. Maybe they mix things up now Rivera is gone but I don't count on it, plus DJ Moore consistently sees 9+ targets anyway. Both Hunt and Golladay have great matchups as well.
I don't like Murray and definitely don't like Brees this week, so might as well go with Allen but it also caps your own upside. Tannehill still available by any chance? If you're really desperately and looking likely to lose, you could go with Manning against the Eagles
And bench Lockett, yeah. Historically he's been bad when playing through injury and that's the case right now again (and he'd face Ramsey). I'd go Singletary if you see what Mostert did to the Ravens last week, but he might not be involved that much if the Bills fall behind early.
How do you miss a bye with CMC and Jackson in your team by the way though.