Put Varane for Martinez on that list. Martinez and Shaw on a lower tier. Bruno below them. We can cover Martinez with Shaw in a short period, as Malacia is quite good. We lose a lot, but still have a good level. If Varane is out then it's an instant big drop off compared to Lindelof of Maguire. Bruno out we'd be pretty ok still with Eriksen/Fred/Casemiro midfield 3, or Sancho as a 10, or Sabitzer and Fred around casemiro to having a super solid midfield group.
Rashford and Casemiro by far the 2 most noticeable losses though. Nobody who can do what they do in our squad. Martial too, arguably, if injured wasn't his natural state.