We've lost the "surprise factor" as before rivals didn't expect him to play and/or didn't know what they were up against. Now they do and someone like Queiroz, with a boring low block side, is going to study him and set things up to deal with him effectively.
Getting doubled up on when coming off an injury and with little if any football, you are bound to struggle, and he did.
In any case, we lost because for some bizarre reason we started Suarez and Nuñez while benching de Arrascaeta and de la Cruz. I'd start Suárez with either of those two in a game like this.
Edit: losing the creativity and build up from those two made it easier to just worry about Pellistri.