I'm actually confused about what is your view on choosing creative box to box over holding midfielder whether it's for short or long term. In my opinion, based on this season's progress so far, we should be looking for to improve our current squad to go toe to toe in the league against Liverpool with VVD fit & Man City. And based on the current squad, what we don't have is holding midfielder because Matic is no longer good enough at his age.
Box to box is a hard-working with good all-round abilities, they are capable to tracking back to make tackles and blocks and also carry the ball forward or run to the opponents box to try to score. That's basically McTominay especially what he has shown against Leeds United. VDB is also in the category which shown the stats below (7 goals and 3 assists in 18 games as box to box in 19/20). While Fred is more of a CM, he doesn't offer end product but he offers passing through the line from deep area, energy to press and defensively very good & discipline but he has big weakness with his composure when making passes and defending a one on one situation to let players dribble past through him with physical strength and dribbling ability.
In my opinion a holding midfielder who has composure on the ball and can defend one on one situation without conceded fouls too often will be able to get the best out of Fred, McT & VDB.