Probably, but that would be most likely be because Mourinho doesn't like to rotate too much. As
@SteveW said, both Herrera and Pereira have put their best performances for us from that position. There're options there.
Pereira looks like he can play the holding midfield role very well. You don't need to be the absolute best defensively to do so. You have to be capable of course, which he's shown, but you don't have to be a focused destroyer.
PSG are playing Veratti in that position. Real are playing Kroos. Barca Busquets. Juventus used to play Pirlo. All these are first and foremost playmakers rather than destroyers. They all play/played in a midfield 3 flanked by players that can mark and also chase the ball. If Pereira plays that position he will most likely be flanked by Pogba and one of Fred/Herrera, so he should be fine.