I mean great for him and I'm also half on the "Feck it, just go for it side" but if he really goes rouge today than JV will have a decision to make in the future regarding his priorities or GC. Yesterday was a prime opportunity to gain time on Pogacar, if they waste another one today they should definitely look at themselves...
Ronde is all about punchy hills, yes on cobbles but I'd argue they're kinda overrated in Flanders (blasphemy to say I know
). This like Roubaix is all about rougher cobbles on flat passages, something which should suit Pogacar less. A superior team (lets face it, UAE is shit) is definitely capable of making a difference but like always many other factors play a role.
Given that many teams will also looking for a stage win today I think even when Pogacar is isolated he'll be able to join chasing groups. And I trust his abilities and tactical awareness more than Roglic.